Overview and prospects of an in vitro cell model for studying liver fibrosis / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 668-672, 2023.
Article
in Zh
| WPRIM
| ID: wpr-986190
Responsible library:
WPRO
ABSTRACT
Liver fibrosis incidence and adverse outcomes are high; however, there are no known chemical drugs or biological agents that are specific and effective for treatment. The paucity of a robust and realistic in vitro model for liver fibrosis is one of the major causes hindering anti-liver fibrosis drug development. This article summarizes the latest progress in the development of in vitro cell models for liver fibrosis, with a focus based on the analysis of induction and activation of hepatic stellate cells, cell co-culture, and 3D model co-construction, as well as concurrent potential methods based on hepatic sinusoidal endothelial cell establishment.
Key words
Full text:
1
Database:
WPRIM
Main subject:
Cell Culture Techniques
/
Endothelial Cells
/
Hepatic Stellate Cells
/
Liver Cirrhosis
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2023
Document type:
Article