Novel biomarkers of sepsis-associated acute respiratory distress syndrome / 中国小儿急救医学
Chinese Pediatric Emergency Medicine
; (12): 957-962, 2022.
Article
in Zh
| WPRIM
| ID: wpr-990456
Responsible library:
WPRO
ABSTRACT
Acute respiratory distress syndrome(ARDS)is one of the most common complications of sepsis, resulting in the high risk of death in patients with sepsis.By comparison with non-septic ARDS, sepsis-associated ARDS is characterized by high morbidity, heterogeneity and mortality.It is vital to early identify the occurrence of ARDS, accurately assess the severity, as well as effectively implement the individualized treatment.Based on the genome-wide association study, mass cytometry, and multiple omics data analysis, the molecular signatures of sepsis-associated ARDS have been elucidated, which were related to genetic susceptibility, inflammatory reaction pathway, and metabolic characteristics.The development of novel biomarkers is helpful to molecular classifier, risk stratification, early recognition and assessing severity, implement early intervention, then improving the prognosis.
Full text:
1
Database:
WPRIM
Language:
Zh
Journal:
Chinese Pediatric Emergency Medicine
Year:
2022
Document type:
Article