The relationship of neutrophil to lymphocyte ratio with testicular cancer
Int. braz. j. urol
; 46(1): 101-107, Jan.-Feb. 2020. tab, graf
Article
in En
| LILACS
| ID: biblio-1056359
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Purpose:
To assess the relationship between testicular germ cell tumors (TGCT) and neutrophil to lymphocyte ratio (NLR) and to determine whether this ratio can be used as a serum tumor marker. Material andMethods:
Sixty-one patients with testicular germ cell tumors were included into the study. Patients were grouped as localized and non-localized. Histologically patients were categorized as seminoma and nonseminomatous germ cell tumors. Complete blood cell count was measured the day before surgery and at the postoperative 1st month. Preoperative and postoperative mean NLR values were compared.Results:
Thirty-six patients (59%) had seminomas and 25 patients (41%) had nonseminomatous testicular cancer. Forty-five patients (73.8%) had localized and 16 patients (26.2%) had non-localized testicular cancer. There was a statistically significant difference between preoperative and postoperative mean NLR of the localized patients (p=0.001) but no such difference was detected for non-localized patients (p=0.576). Nineteen patients with localized seminomas had normal preoperative serum tumor markers. There was a significant difference between preoperative and postoperative mean NLR in this group of patients (p=0.010). Twenty-six patients with localized tumors had preoperative increased serum tumor markers which normalized after orchiectomy. Mean NLR of these patients significantly decreased from 3.10±2.13 to 1.62±0.59 postoperatively (p=0.010).Conclusions:
NLR appears to be a useful marker for TGCT. It is successful in predicting localized and non-localized disease in early postoperative period.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Testicular Neoplasms
/
Lymphocytes
/
Seminoma
/
Neoplasms, Germ Cell and Embryonal
/
Neutrophils
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
En
Journal:
Int. braz. j. urol
Journal subject:
UROLOGIA
Year:
2020
Document type:
Article
Affiliation country:
Turkey