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Mycobacterium tuberculosis spoligotypes and drug-resistant characterization from Beira compared to genotypes circulating in Mozambique
Anselmo, Lívia Maria Pala; Conceição, Emilyn Costa; Namburete, Evangelina; Feliciano, Cinara; Spindola, Silvana; Sola, Christophe; Bollela, Valdes Roberto.
Affiliation
  • Anselmo, Lívia Maria Pala; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Medicina Interna. Ribeirão Preto. BR
  • Conceição, Emilyn Costa; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo Góes. Rio de Janeiro. BR
  • Namburete, Evangelina; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Medicina Interna. Ribeirão Preto. BR
  • Feliciano, Cinara; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Medicina Interna. Ribeirão Preto. BR
  • Spindola, Silvana; Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Medicina Interna. Belo Horizonte. BR
  • Sola, Christophe; Université Paris-Saclay. Institute for Integrative Biology of the Cell (I2BC). CEA, CNRS, Univ. Paris-Sud. Gif-sur-Yvette cedex. FR
  • Bollela, Valdes Roberto; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Medicina Interna. Ribeirão Preto. BR
Rev. Soc. Bras. Med. Trop ; 52: e20190257, 2019. tab, graf
Article in En | LILACS | ID: biblio-1057252
Responsible library: BR1.1
ABSTRACT
Abstract INTRODUCTION Mozambique is one of three countries with high prevalence of tuberculosis (TB), TB/human immunodeficiency virus coinfection, and multidrug-resistant TB. We aimed to describe Mycobacterium tuberculosis spoligotypes circulating among drug resistant (DR) strains from Beira, Mozambique comparing them with genotypes in the country.

METHODS:

We performed spoligotyping of 79 M. tuberculosis suspected of DR-TB compared all spoligotype patterns published on the international database and PubMed.

RESULTS:

Both in Beira and Mozambique (n=578), the main clades were Latin-American-Mediterranean, East-African-Indian, Beijing and T, with no extensively DR TB cases.

CONCLUSIONS:

Beira and Mozambique share the same population genetic structure of M. tuberculosis.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Genetic Variation / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Type of study: Risk_factors_studies Limits: Humans Country/Region as subject: Africa Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2019 Document type: Article Affiliation country: Brazil / France Country of publication: Brazil
Fulltext
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Genetic Variation / Tuberculosis, Multidrug-Resistant / Mycobacterium tuberculosis Type of study: Risk_factors_studies Limits: Humans Country/Region as subject: Africa Language: En Journal: Rev. Soc. Bras. Med. Trop Journal subject: MEDICINA TROPICAL Year: 2019 Document type: Article Affiliation country: Brazil / France Country of publication: Brazil