Factores asociados a la presencia de fisura labiopalatina en recién nacidos en un hospital peruano de tercer nivel de atención. Un estudio de casos y controles / Factors associated to the occurrence of cleft lip and palate in newborns in a tertiary care Peruvian hospital. A case-control study
Acta méd. peru
; 37(3): 304-311, jul-sep 2020. tab
Article
in Spanish
|
LILACS-Express
| LILACS
| ID: biblio-1142015
Responsible library:
PE1.1
RESUMEN
RESUMEN Objetivo:
identificar los factores asociados a la presencia de fisura labial y/o palatina en recién nacidos en el Hospital Nacional Edgardo Rebagliati Martins, localizado en Lima - Perú, durante el periodo noviembre 2012 - diciembre 2016. Materiales ymétodos:
estudio observacional, analítico, de casos y controles emparejado, con datos del Estudio Colaborativo Latinoamericano de Malformaciones Congénitas (ECLAMC). Se analizaron 61 casos y 61 controles. La variable dependiente fue la presencia de fisura labial y/o palatina. Se recogieron también variables clínicas, epidemiológicas, obstétricas y prenatales.Resultados:
la fisura labiopalatina con extensión completa, en el sexo masculino, fue la forma más frecuente y estuvo presente en 36 neonatos (59%), con cariotipo normal 44 (75,9%) y sin diagnóstico prenatal 40 (65,6%). Las malformaciones observadas con más frecuencia fueron las faciales 27 (44,2%) seguidas de malformaciones cardiacas (29,6%). Se construyó un modelo estadístico mediante análisis multivariado conformado por tres variables enfermedad crónica durante el embarazo (odds ratio (OR) 3,8; intervalo de confianza al 95% (IC 95%) 1,11 - 13,08), edad materna mayor a 35 años (OR 6,85; IC 95% 2,69 - 17,43) y antecedente familiar (OR 14,5; IC 95% 1,68 - 125,56).Conclusiones:
las enfermedades crónicas en el embarazo, la edad materna avanzada y el antecedente familiar fueron factores que aumentaron la presencia de fisura labial y/o palatina.ABSTRACT
ABSTRACT Objective:
to identify factors associated to the occurrence of cleft lip and/or palate in newborns in Edgardo Rebagliati-Martins National Hospital in Lima, Peru, during the time period from November 2012 until December 2016. Materials andmethods:
this is an analytical observational paired case-control study, with data from the Collaborative Latin-American Study of Congenital Malformations. Sixty-one cases and sixty-one controls were analyzed. The dependent variable was the presence of cleft lip and/or palate. Clinical, epidemiological, obstetric, and prenatal variables were also analyzed.Results:
cleft lip/palate with complete extension predominantly in males was the most frequent form, and it was present in 36 neonates (59%), 44 of all children in the sample (75.9%) had normal karyotype, and 40 did not have a prenatal diagnosis (65.6%). Associated malformations most frequently observed were 27 facial cases (44.2%), followed by cardiac malformations (29.6%). A statistical model using multivariate analysis was built on, and this comprised three variables chronic disease during pregnancy (odds ratio (OR) 3.8; 95% confidence interval (CI) 1.11-13.8), maternal age more than 35 years (OR 6.85; 95% CI 2.69-17.43), and family history (OR 14.5; 95% CI 1.68-125.56).Conclusions:
chronic diseases during pregnancy, advanced maternal age, and family history were factors that increased the frequency of cleft lip and/or palate.
Full text:
Available
Collection:
International databases
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 9: Noncommunicable diseases and mental health
Database:
LILACS
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
South America
/
Peru
Language:
Spanish
Journal:
Acta méd. peru
Journal subject:
Medicine
Year:
2020
Document type:
Article
Affiliation country:
Peru
Institution/Affiliation country:
Universidad Nacional Pedro Ruiz Gallo/PE
/
Universidad Señor de Sipán/PE
/
Universidad Tecnológica del Perú/PE