Reacciones adversas a montelukast: de la teoría a la práctica. Serie de casos / Adverse drug reactions of montelukast: from theory to practice. Case report
Arch. argent. pediatr
; 119(4): e357-e359, agosto 2021.
Article
in Es
| LILACS, BINACIS
| ID: biblio-1281895
Responsible library:
AR94.1
RESUMEN
El montelukast se utiliza ampliamente en el tratamiento de sibilancias recurrentes y/o asma. Están descritas numerosas reacciones adversas medicamentosas (RAM) en niños relacionadas con montelukast; se destacan las neuropsiquiátricas. Realizamos un estudio observacional, retrospectivo, descriptivo, sobre RAM relacionadas con montelukast. Entre enero de 2012 y diciembre de 2017, en la Unidad de Neumonología Pediátrica se trataron con Montelukast 348 pacientes; de ellos, 20 presentaron RAM. Los síntomas más frecuentes fueron insomnio (n = 7), hiperactividad (n = 4), pesadillas (n = 3), dolor abdominal (n = 2) y parestesias en extremidades (n = 2). Se presentaron desde días hasta meses tras iniciar el tratamiento, y desaparecieron tras su suspensión. Se destacan dos pacientes con parestesias en extremidades, síntoma no descrito antes en niños. El 5,7 % de los pacientes tratados con montelukast presentaron RAM que requirieron suspender el tratamiento. Los trastornos del sueño fueron los más frecuentes.
ABSTRACT
Montelukast is widely used in recurrent wheezing and/or asthma treatment. Several adverse drug reactions (ADRs) have been described in children related to montelukast. Neuropsychiatric reactions are one of the most important. We designed an observational, retrospective, descriptive study on ADRs related to montelukast in the Pediatric Pulmonology Unit, Hospital Universitario Miguel Servet, Zaragoza, Spain. Between January 2012 and December 2017, in the Pediatric Pulmonology Unit, 348 patients were treated with Montelukast; of them, 20 presented RAM. The main symptoms described were insomnia (n = 7), hyperactivity (n = 4), nightmares (n = 3), abdominal pain (n = 2) and paraesthesia in extremities (n = 2). They appeared from the first days to months after the start of treatment and disappeared after stopping it. Two patients presented limb paresthesia, not described previously in children. The 5.7 % of our patients treated with montelukast had ADRs that required treatment discontinuation. Sleep disorders were the most frequent.
Key words
Antagonistas de leucotrieno; Child; Drug-related side effects and adverse reactions; Efectos colaterales y reacciones adversas relacionados con medicamentos; Leukotriene antagonists; Montelukast; Montelukast; Niño; Sleep initiation and maintenance disorders; Trastornos del inicio y del mantenimiento del sueño
Full text:
1
Collection:
01-internacional
Database:
BINACIS
/
LILACS
Main subject:
Quinolines
/
Sulfides
/
Anti-Asthmatic Agents
/
Leukotriene Antagonists
/
Cyclopropanes
/
Acetates
Type of study:
Observational_studies
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Language:
Es
Journal:
Arch. argent. pediatr
Journal subject:
PEDIATRIA
Year:
2021
Document type:
Article
Affiliation country:
Spain
Country of publication:
Argentina