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Bioactivities of Alchemilla mollis, Alchemilla persica and Their Active Constituents
Kurtul, Ekin; Eryilmaz, Müjde; Sarialtin, Sezen Yilmaz; Teki̇n, Mehmet; Acikara, Özlem Bahadir; Çoban, Tülay.
Affiliation
  • Kurtul, Ekin; Ankara University. Faculty of Pharmacy. Department of Pharmacognosy. Ankara. TR
  • Eryilmaz, Müjde; Ankara University. Faculty of Pharmacy. Department of Pharmaceutical Microbiology. Ankara. TR
  • Sarialtin, Sezen Yilmaz; Ankara University. Faculty of Pharmacy. Department of Pharmaceutical Toxicology. Ankara. TR
  • Teki̇n, Mehmet; Trakya University. Faculty of Pharmacy. Department of Pharmaceutical Botany. Edirne. TR
  • Acikara, Özlem Bahadir; Ankara University. Faculty of Pharmacy. Department of Pharmacognosy. Ankara. TR
  • Çoban, Tülay; Ankara University. Faculty of Pharmacy. Department of Pharmaceutical Toxicology. Ankara. TR
Braz. J. Pharm. Sci. (Online) ; 58: e18373, 2022. tab
Article in English | LILACS | ID: biblio-1364428
Responsible library: BR40.1
Localization: BR40.1
ABSTRACT
Abstract The aim of this study was to determine antimicrobial activities of Alchemilla mollis, Alchemilla persica as well as ellagic acid and miquelianin against Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans by using microbroth dilution method and anti-inflammatory activity by using human red blood cell (HRBC) membrane stabilization method. Microbroth dilution method was used to determine the antimicrobial activities. Extracts possessed activity having MIC values of 2.5-5-10mg/ mL, compounds possessed activity having MIC values of 1.25-2.5-4-5mg/mL. A.mollis aerial parts displayed the highest anti-inflammatory activity (IC50=1.22±0.07mg/mL). Ellagic acid and miquelianin were also determined as anti-inflammatory agents with 0.57±0.01mg/mL and 1.23±0.02mg/mL IC50 values, respectively. Total phenolic content and tannin content of the A.mollis and A.persica were determined as 357.00±75.80mg, 282.50±28.70mg PGE/g plant material and 18.02%, 18.63% respectively according to the method described by European Pharmacopoeia. Ellagic acid, miquelianin and catechin were analyzed by HPLC. The highest catechin content was detected in A.persica roots (6.69±0.05g/100g plant material). A.mollis aerial parts contain higher miquelianin (0.39±0.02g/plant material) and ellagic acid (1.56±0.01g/ plant material) than A.persica.
Subject(s)


Full text: Available Collection: International databases Database: LILACS Main subject: Alchemilla Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Document type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara University/TR / Trakya University/TR

Full text: Available Collection: International databases Database: LILACS Main subject: Alchemilla Language: English Journal: Braz. J. Pharm. Sci. (Online) Journal subject: Farmacologia / Terapˆutica / Toxicologia Year: 2022 Document type: Article Affiliation country: Turkey Institution/Affiliation country: Ankara University/TR / Trakya University/TR
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