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Influence of antidepressant drugs on DNA methylation of ion channels genes in blood cells of psychiatric patients
Nascimento, Larissa Vilela; Neto, Francisco Lotufo; Moreira, Dalmo Antonio Ribeiro; Cerutti, Virginia Braga; Thurow, Helena Strelow; Bastos, Gisele Medeiros; Ferreira, Eric Batista; Hirata, Rosario Dominguez Crespo; Hirata, Mario Hiroyuki.
Affiliation
  • Nascimento, Larissa Vilela; Department of Clinical e Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo. São Paulo. BR
  • Neto, Francisco Lotufo; Institute of Psychiatry, School of Medicine, University of São Paulo. São Paulo. BR
  • Moreira, Dalmo Antonio Ribeiro; Department of Electrophysiology & Cardiac Arrhythmias, Institute Dante Pazzanese of Cardiology. São Paulo. BR
  • Cerutti, Virginia Braga; Department of Electrophysiology & Cardiac Arrhythmias, Institute Dante Pazzanese of Cardiology. São Paulo. BR
  • Thurow, Helena Strelow; Department of Teaching & Research, Real e Benemerita Associação Portuguesa de Beneficiência. São Paulo. BR
  • Bastos, Gisele Medeiros; Department of Teaching & Research, Real e Benemerita Associação Portuguesa de Beneficiência. São Paulo. BR
  • Ferreira, Eric Batista; Institute of Exact Sciences, Federal University of Alfenas. Alfenas. BR
  • Hirata, Rosario Dominguez Crespo; Department of Clinical e Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo. São Paulo. BR
  • Hirata, Mario Hiroyuki; Department of Clinical e Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo. São Paulo. BR
Epigenomics (Online) ; 14(14)July 2022.
Article in English | CONASS, Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP | ID: biblio-1381722
Responsible library: BR79.1
ABSTRACT
ABSTRACT

AIM:

This study investigated the influence of antidepressant drugs on methylation status of KCNE1, KCNH2 and SCN5A promoters and ECG parameters in adult psychiatric patients. MATERIALS &

METHODS:

Electrocardiographic evaluation (24 h) and blood samples were obtained from 34 psychiatric patients before and after 30 days of antidepressant therapy. Methylation of promoter CpG sites of KCNE1, KCNH2 and SCN5A was analyzed by pyrosequencing.

RESULTS:

Three CpG and four CpG sites of KCNE1 and SCN5A, respectively, had increased % methylation after treatment. Principal component analysis showed correlations of the methylation status with electrocardiographic variables, antidepressant doses and patient age.

CONCLUSION:

Short-term treatment with antidepressant drugs increase DNA methylation in KCNE1 and SCN5A promoters, which may induce ECG alterations in psychiatric patients.
Subject(s)
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Collection: National databases / Brazil Database: CONASS / Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Antidepressive Agents Limits: Adult / Humans Language: English Journal: Epigenomics (Online) Year: 2022 Document type: Article Institution/Affiliation country: Department of Clinical e Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo/BR / Department of Electrophysiology & Cardiac Arrhythmias, Institute Dante Pazzanese of Cardiology/BR / Department of Teaching & Research, Real e Benemerita Associação Portuguesa de Beneficiência/BR / Institute of Exact Sciences, Federal University of Alfenas/BR / Institute of Psychiatry, School of Medicine, University of São Paulo/BR
Search on Google
Add to My VHL
Print
XML

Collection: National databases / Brazil Database: CONASS / Sec. Est. Saúde SP / SESSP-IDPCPROD Main subject: Antidepressive Agents Limits: Adult / Humans Language: English Journal: Epigenomics (Online) Year: 2022 Document type: Article Institution/Affiliation country: Department of Clinical e Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo/BR / Department of Electrophysiology & Cardiac Arrhythmias, Institute Dante Pazzanese of Cardiology/BR / Department of Teaching & Research, Real e Benemerita Associação Portuguesa de Beneficiência/BR / Institute of Exact Sciences, Federal University of Alfenas/BR / Institute of Psychiatry, School of Medicine, University of São Paulo/BR