The hematologic profile of Filipino HIV-infected individuals and its association with CD4 counts
Hematol., Transfus. Cell Ther. (Impr.)
; 44(3): 307-313, July-Sept. 2022. tab
Article
in En
| LILACS
| ID: biblio-1404986
Responsible library:
BR408.1
Localization: BR408.1
ABSTRACT
ABSTRACT Introduction:
Hematologic abnormalities are common in HIV and involve all blood cell lineages. A study on cytopenias, as correlated with disease progression, can be valuable in resource-limited settings. This study aimed to determine the hematologic profile of HIV patients and its association with CD4 count and antiretroviral (ARV) treatment.Methods:
This is a retrospective cohort study involving adult Filipino HIV patients with complete blood count (CBC) and CD4 count determinations prior to the initiation of ARV treatment and after ≥6 months of ARV treatment. Logistic regression was performed to determine the association between cytopenias and a CD4 count <200 cells/μL.Results:
The study included 302 patients. Anemia was the most common cytopenia. Anemia and leukopenia were associated with an increased likelihood of having a CD4 count <200 cells/μL in ARV-naïve patients. In ARV-treated patients, leukopenia was associated with an increased probability of having a CD4 count <200 cells/μL. An increase in hemoglobin, white blood cell (WBC) and platelet counts was observed after ≥6 months of ARV treatment.Conclusion:
Anemia and leukopenia can be used as markers of immune status in HIV-infected individuals and improvement in the CBC parameters can be used to assess response to ARV treatment. Routine monitoring of hematologic parameters is recommended.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
HIV Infections
/
Antiretroviral Therapy, Highly Active
/
Leukopenia
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
En
Journal:
Hematol Transfus Cell Ther
/
Hematol., Transfus. Cell Ther. (Impr.)
/
Hematology, Transfusion and Cell Therapy (Impresso)
/
Hematology, Transfusion and Cell Therapy (Online)
Journal subject:
Hematologia
/
TransfusÆo de Sangue
Year:
2022
Document type:
Article
Affiliation country:
Philippines
Country of publication:
Brazil