Temporal progression of sepsis on critical care COVID-19 patients: a retrospective cohort study
Rev. Assoc. Med. Bras. (1992, Impr.)
; 68(10): 1458-1463, Oct. 2022. tab, graf
Article
in En
|
LILACS-Express
| LILACS
| ID: biblio-1406549
Responsible library:
BR1.1
ABSTRACT
SUMMARY OBJECTIVE:
This study aimed to describe sepsis progression in critical COVID-19 patients using the SOFA score and investigate its relationship with mortality.METHODS:
Three researchers collected and analyzed retrospective clinical and laboratory data found in electronic health records from all patients admitted to a severe COVID-19 exclusive intensive care unit from March 2020 to October 2020. Mixed-effect logistic regression was used to evaluate SOFA (Sepsis-3) score variables as mortality prediction markers, while Kaplan-Meier survival curves were used to compare mortality between groups of patients. Cox proportional hazard models were used to further stratify mortality association between variants.RESULTS:
A total of 73 patients were included. Temporal COVID-19-related sepsis progression analysis indicates difference in degrees and timing between different organ dysfunction over time. Sepsis-3 Cardiovascular Dysfunction characterized by severe hypotension added to the use of any vasopressor drugs was the only parameter associated with in-hospital death during the first 5 days of hospital admission (OR 2.19; 95%CI 1.14-4.20; p=0.01).CONCLUSION:
Increased Sepsis-3 Cardiovascular Dysfunction score, characterized as hypotension associated with the use of vasopressor drugs in the first days of intensive care unit stay, is related to higher mortality in COVID-19 patients and may be a useful prognostic prediction tool.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Type of study:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
MEDICINA
Year:
2022
Document type:
Article
Affiliation country:
Brazil
Country of publication:
BR
/
BRASIL
/
BRASILE
/
BRAZIL
/
BRESIL