Association between antibiotic prophylaxis and adverse perinatal outcomes in premature rupture of membranes
Rev. Assoc. Med. Bras. (1992, Impr.)
; 69(1): 24-29, Jan. 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1422610
Responsible library:
BR1.1
ABSTRACT
SUMMARY OBJECTIVE:
The aim of this study was to evaluate the association between antibiotic prophylaxis and adverse perinatal outcomes in premature rupture of membranes.METHODS:
This retrospective cohort included pregnant women with premature rupture of membranes (between 24 and 33+6 weeks) who used or did not use prophylactic antibiotics. Pearson's chi-square (χ²) test, Student's t-test, and binary logistic regression were used for statistical analysis.RESULTS:
A significant effect was observed in patients with premature rupture of membranes using prophylactic antibiotics regarding amniotic fluid index (p=0.007), deepest vertical pocket (p=0.049), duration of antibiotic therapy (p≤0.001), C-reactive protein level upon admission (p≤0.001), leukocyte count upon admission (p=0.007), and length of stay in neonatal intensive care (p=0.047). A significant association was observed between the abovementioned patients and surfactant use during the neonatal period (p=0.04). A higher prevalence of surfactant use was noted in these patients (20.0 vs. 8.7%; p=0.04).CONCLUSION:
No association was found between antibiotic prophylaxis and the presence of adverse perinatal outcomes in pregnant women with premature rupture of membranes between 24 and 33+6 weeks of gestation.
Full text:
Available
Collection:
International databases
Database:
LILACS
Type of study:
Risk factors
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2023
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Sabin Medicina Diagnóstica/BR
/
Universidade Federal de São Paulo/BR
/
Universidade Federal do Triângulo Mineiro/BR
/
Universidade de Uberaba/BR