Genetic recurrence and molecular markers of dyslexia in the Brazilian population
Rev. CEFAC
; 25(2): e8722, 2023. tab, graf
Article
in English
|
LILACS-Express
| LILACS
| ID: biblio-1431266
Responsible library:
BR1.1
ABSTRACT
ABSTRACT Purpose:
to investigate genetic recurrence and molecular markers for dyslexia in two candidate genes in the Brazilian population.Methods:
a cross-sectional, case-control, observational study, with five single nucleotide polymorphisms (SNPs) studied in DYX1C1 and KIAA0319 genes in 86 subjects with dyslexia and 66 controls, matched for gender and age. SNPs were genotyped using the polymerase chain reaction technique in real time, and distribution of genotypic and allelic frequencies between the groups was analyzed.Results:
it was determined that 68% of the subjects with dyslexia present a family history of learning difficulties. The DYX1C1 gene did not demonstrate an association with dyslexia, which was found regarding the rs9461045 marker of the KIAA0319 gene.Conclusion:
a family history of learning problems was present in more than two-thirds of the group with dyslexia, indicating that this is an important risk factor. An association with dyslexia in the rs9461045 marker was noted, making the study the first one to show an association of the KIAA0319 gene with dyslexia, in Latin America.
Full text:
Available
Collection:
International databases
Database:
LILACS
Type of study:
Observational study
/
Risk factors
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. CEFAC
Journal subject:
Terapia
/
Speech-Language Pathology
/
Terapia
/
ReabilitaÆo
Year:
2023
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade São Francisco/BR
/
Universidade de São Paulo/BR