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Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil
Jarrah, Samar Afif; Kmetiuk, Louise Bach; Carvalho, Otávio Valério de; Sousa, Alessandra Tammy Hayakawa Ito de; Souza, Valeria Regia Franco; Nakazato, Luciano; Colodel, Edson Moleta; Santos, Andrea Pires dos; Pettan-Brewer, Christina; Hahn, Rosane Christine; Slhessarenko, Renata Dezengrini; Ubiali, Daniel Guimarães; Pereira, Asheley Henrique Barbosa; Morais, Helio Autran de; Biondo, Alexander Welker; Dutra, Valéria.
Affiliation
  • Jarrah, Samar Afif; s.af
  • Kmetiuk, Louise Bach; s.af
  • Carvalho, Otávio Valério de; s.af
  • Sousa, Alessandra Tammy Hayakawa Ito de; s.af
  • Souza, Valeria Regia Franco; s.af
  • Nakazato, Luciano; s.af
  • Colodel, Edson Moleta; s.af
  • Santos, Andrea Pires dos; s.af
  • Pettan-Brewer, Christina; s.af
  • Hahn, Rosane Christine; s.af
  • Slhessarenko, Renata Dezengrini; s.af
  • Ubiali, Daniel Guimarães; s.af
  • Pereira, Asheley Henrique Barbosa; s.af
  • Morais, Helio Autran de; s.af
  • Biondo, Alexander Welker; s.af
  • Dutra, Valéria; s.af
Article in En | LILACS-Express | LILACS, VETINDEX | ID: biblio-1484795
Responsible library: BR68.1
ABSTRACT
Abstract

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen.

Conclusion:

The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.
Key words
Full text: 1 Database: LILACS / VETINDEX Type of study: Prognostic_studies Country/Region as subject: America do sul / Brasil Language: En Journal: J. venom. anim. toxins incl. trop. dis Year: 2022 Document type: Article
Full text: 1 Database: LILACS / VETINDEX Type of study: Prognostic_studies Country/Region as subject: America do sul / Brasil Language: En Journal: J. venom. anim. toxins incl. trop. dis Year: 2022 Document type: Article