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COVID-19 outcomes in people living with HIV: Peering through the waves
Sales, Thaís Lorenna Souza; Souza-Silva, Maíra Viana Rego; Delfino-Pereira, Polianna; Neves, João Victor Baroni; Sacioto, Manuela Furtado; Assis, Vivian Costa Morais de; Duani, Helena; Oliveira, Neimy Ramos de; Sampaio, Natália da Cunha Severino; Ramos, Lucas Emanuel Ferreira; Schwarzbold, Alexandre Vargas; Jorge, Alzira de Oliveira; Scotton, Ana Luiza Bahia Alves; Castro, Bruno Mateus de; Silva, Carla Thais Cândida Alves da; Ramos, Carolina Marques; Anschau, Fernando; Botoni, Fernando Antonio; Grizende, Genna Maira Santos; Nascimento, Guilherme Fagundes; Ruschel, Karen Brasil; Menezes, Luanna Silva Monteiro; Castro, Luís César de; Nasi, Luiz Antônio; Carneiro, Marcelo; Godoy, Mariana Frizzo de; Nogueira, Matheus Carvalho Alves; Guimarães Júnior, Milton Henriques; Ziegelmann, Patricia Klarmann; Almeida, Rafaela Charão de; Francisco, Saionara Cristina; Silveira Neto, Sidney Teodoro; Araújo, Silvia Ferreira; Avelino-Silva, Thiago Junqueira; Aliberti, Márlon Juliano Romero; Pires, Magda Carvalho; Silva, Eduardo Sérgio da; Marcolino, Milena Soriano.
Affiliation
  • Sales, Thaís Lorenna Souza; Universidade Federal de São João del-Rei. Divinópolis. BR
  • Souza-Silva, Maíra Viana Rego; Universidade Federal de Minas Gerais. Medical School. Department of Internal Medicine. Belo Horizonte. BR
  • Delfino-Pereira, Polianna; Instituto de Avaliação de Tecnologia em Saúde. Porto Alegre. BR
  • Neves, João Victor Baroni; Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte. BR
  • Sacioto, Manuela Furtado; Hospital Eduardo de Menezes. Belo Horizonte. BR
  • Assis, Vivian Costa Morais de; Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte. BR
  • Duani, Helena; Universidade Federal de Minas Gerais. Medical School. Department of Internal Medicine. Belo Horizonte. BR
  • Oliveira, Neimy Ramos de; Hospital Eduardo de Menezes. Belo Horizonte. BR
  • Sampaio, Natália da Cunha Severino; Hospital Eduardo de Menezes. Belo Horizonte. BR
  • Ramos, Lucas Emanuel Ferreira; Universidade Federal de Minas Gerais. Department of Statistics. Belo Horizonte. BR
  • Schwarzbold, Alexandre Vargas; Hospital Universitário de Santa Maria. Santa Maria. BR
  • Jorge, Alzira de Oliveira; Hospital Risoleta Tolentino Neves. Belo Horizonte. BR
  • Scotton, Ana Luiza Bahia Alves; Hospital Regional Antônio Dias. Patos de Minas. BR
  • Castro, Bruno Mateus de; Hospital de Clínicas de Porto Alegre. Porto Alegre. BR
  • Silva, Carla Thais Cândida Alves da; Hospital Santo Antônio. Curvelo. BR
  • Ramos, Carolina Marques; Faculdade de Ciências Médicas de Minas Gerais. Belo Horizonte. BR
  • Anschau, Fernando; Hospital Nossa Senhora da Conceição. Porto Alegre. BR
  • Botoni, Fernando Antonio; Hospital Julia Kubitschek. Belo Horizonte. BR
  • Grizende, Genna Maira Santos; Hospital Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte. BR
  • Nascimento, Guilherme Fagundes; Hospital UNIMED BH. Belo Horizonte. BR
  • Ruschel, Karen Brasil; Hospital Mãe de Deus. Porto Alegre. BR
  • Menezes, Luanna Silva Monteiro; Hospital Metropolitano Odilon Behrens. Belo Horizonte. BR
  • Castro, Luís César de; Hospital Bruno Born. Lajeado. BR
  • Nasi, Luiz Antônio; Hospital Moinhos de Vento. Porto Alegre. BR
  • Carneiro, Marcelo; Hospital Santa Cruz. Santa Cruz do Sul. BR
  • Godoy, Mariana Frizzo de; Hospital São Lucas PUCRS. Porto Alegre. BR
  • Nogueira, Matheus Carvalho Alves; Hospitais da Rede Mater Dei. Belo Horizonte. BR
  • Guimarães Júnior, Milton Henriques; Hospital Márcio Cunha. Ipatinga. BR
  • Ziegelmann, Patricia Klarmann; Hospital Tacchini. Bento Gonçalves. BR
  • Almeida, Rafaela Charão de; Hospital Nossa Senhora da Conceição. Porto Alegre. BR
  • Francisco, Saionara Cristina; Hospital Metropolitano Doutor Célio de Castro. Belo Horizonte. BR
  • Silveira Neto, Sidney Teodoro; Universidade Federal de São João Del-Rei. Medical School. Divinópolis. BR
  • Araújo, Silvia Ferreira; Hospital Semper. Belo Horizonte. BR
  • Avelino-Silva, Thiago Junqueira; Universidade de São Paulo. Faculdade de Medicina. Laboratório de Investigação Médica em Envelhecimento, Hospital das Clínicas HCFMUSP. São Paulo. BR
  • Aliberti, Márlon Juliano Romero; Universidade de São Paulo. Faculdade de Medicina. Laboratório de Investigação Médica em Envelhecimento, Hospital das Clínicas HCFMUSP. São Paulo. BR
  • Pires, Magda Carvalho; Universidade Federal de Minas Gerais. Department of Statistics. Belo Horizonte. BR
  • Silva, Eduardo Sérgio da; Universidade Federal de São João del-Rei. Divinópolis. BR
  • Marcolino, Milena Soriano; Instituto de Avaliação de Tecnologia em Saúde. Porto Alegre. BR
Clinics ; Clinics;78: 100223, 2023. tab, graf
Article in En | LILACS-Express | LILACS | ID: biblio-1506013
Responsible library: BR1.1
ABSTRACT
Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 41). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR 43.0;64.0) years in 2020 and 53 (IQR 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group.
Key words

Full text: 1 Collection: 01-internacional Database: LILACS Type of study: Clinical_trials / Risk_factors_studies Language: En Journal: Clinics Journal subject: MEDICINA Year: 2023 Document type: Article / Project document Affiliation country: Brazil Country of publication: Brazil

Full text: 1 Collection: 01-internacional Database: LILACS Type of study: Clinical_trials / Risk_factors_studies Language: En Journal: Clinics Journal subject: MEDICINA Year: 2023 Document type: Article / Project document Affiliation country: Brazil Country of publication: Brazil