Effect of Hepatitis B Vaccination on HBV-infection among school children in Yaounde ten years after its introduction of the HBV vaccine into routine Immunization Program in Cameroon
Pan Afr. med. j
; 472024.
Article
in En
| AIM
| ID: biblio-1551896
Responsible library:
CG1.1
ABSTRACT
Introduction:
since the introduction of the anti-HBV vaccine into the Expanded Program on Immunization (EPI) in 2005 in Cameroon, vaccination coverage has reached 99.0%. This coverage would indicate an increase the number of children immune to Hepatitis B Virus (HBV) and a decrease in susceptibility to HBV-infection. This study was conducted to evaluate the effect of the HBV vaccine on pediatric HBV-infection in Yaounde, Cameroon.Methods:
this school based cross-sectional study was conducted from February to May 2016 among 180 children from Nkomo public school. The study population was stratified into two groups vaccinated (n=95) versus (vs) unvaccinated (n=85). Screening for HBV biomarkers was done using a rapid panel test for detection (HBsAg, HBeAg and anti-HBc) and anti-HBs titer using enzyme linked immunosorbent assay (ELISA). Statistical analyses were done using SPSS v. 22 with p ≥0.05 considered significant.Results:
the mean age was 9.65 years. HBsAg (p=0.019) and anti-HBc (p=0.001) rates were detected in children aged ≥10 years and children aged < 10 years (95.95% [71/74]) were vaccinated vs 22.64% (24/106) for those aged ≥10 years (OR 80.86; 95% CI 23.36%-279.87%, p < 0.0001). According to anti-HBV vaccination status, HBsAg rate varied from [9.41% (8/85) to 1.05% (1/95), p=0.025], HBeAg rate varied from [2.35% (2/85) to 0% (0/95), p= 0.42] and anti-HBc rate ranged from [12.94% (11/85) to 2.10% (2/95), p= 0.011].Conclusion:
despite the variability of the anti-HBs titer, vaccination against HBV has a positive effect on the reduction of HBV infection in children in tropical settings such as Cameroon.
Fulltext
- https://www.panafrican-med-journal.com//content/article/47/169/full/
- https://indexmedicus.afro.who.int/iah/fulltext/Effect of Hepatitis B Vaccination on HBV-infection among school children in Yaounde ten years after its introduction of the HBV vaccine into routine Immunization Program in Cameroon_Nguwoh P S.pdf
- https://fi-admin.bvsalud.org/document/view/gc2xg
Full text:
1
Database:
AIM
Main subject:
Hepatitis B
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Pan Afr Med J
/
Pan Afr. med. j
/
The Pan African medical journal
Year:
2024
Document type:
Article