Interference of the blood clot on granulation tissue formation after tooth extraction: histomorphological study in rats / Interferência do coágulo sangüíneo na formação do tecido de granulação após extração dentária: estudo histomorfológico em ratos

ABSTRACT

The interference of a blood clot in the first postoperative hours of denta extraxtion wounds was studied in rats. Sixty male albino rats were divided into two groupsGroup I, immediately after extraction of maxillary of right maxillary incisor the gingival mucosa was approximated and sutured; Group II, after 6 to 8 minutoes postoperatively the blood clot was removed with saline irrigation and absorbent paper cones. The mucosa was then approximated and sutured. Six animals in each group were sacrificed after 12 hours, 1, 4, 7 and 10 days. There was a profound delay in healing in Group II since, although a new blood clot was later formed, it was not organized. The quality and the constitution, maintenance and retraction of the clot are the regulating factors in connective tissue formation during alveolar healing