Effects of fibrin adhesive material (Tissucol) on alveolar healing in rats under stress / Efeitos do material adesivo de fibra (Tissucol) na cicatrização alveolar de ratos sob stress

ABSTRACT

The effects of Tissucol on alveolar healing following stress were evaluated histologically, comparing tree groups of 28 male albino rats each. Stress was applied and their rigth upper incisors were extracteds. Group A served as an empty control side. In Group B, Tissucol was applied into the alveolar cavity. Group C received local antifibrinolytic treatment (alveolar irrigation with epsilonaminocaproic solution) before implants Tissucol into the tooth socket point. Four animal in each group were killed at 1, 3, 6, 9, 15, 21 and 24 days after surgery. Results showed that 1) Tissucol did not interfere with connective and osseous tissue formation; 2) Tissucol allowed new bone formation; 3) Tissucol residues in Group B in sections of 24-days especimens did not impair healing; 4) Tissucol was usually completely resorbed and healing was complete 24 days after surgery in Group C