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Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats
Peixoto, TC; Moura, EG; Oliveira, E; Younes-Rapozo, V; Soares, PN; Rodrigues, VST; Santos, TR; Peixoto-Silva, N; Carvalho, JC; Calvino, C; Conceição, EPS; Guarda, DS; Claudio-Neto, S; Manhães, AC; Lisboa, PC.
Affiliation
  • Peixoto, TC; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Moura, EG; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Oliveira, E; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Younes-Rapozo, V; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Soares, PN; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Rodrigues, VST; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Santos, TR; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Peixoto-Silva, N; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Carvalho, JC; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Calvino, C; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Conceição, EPS; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Guarda, DS; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Claudio-Neto, S; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Manhães, AC; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
  • Lisboa, PC; Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Laboratório de Fisiologia Endócrina. Rio de Janeiro. BR
Braz. j. med. biol. res ; 51(6): 6982, 2018. tab, graf
Article in English | LILACS | ID: biblio-889095
Responsible library: BR1.1
ABSTRACT
Maternal smoking is a risk factor for progeny obesity. We have previously shown, in a rat model of neonatal tobacco smoke exposure, a mild increase in food intake and a considerable increase in visceral adiposity in the adult offspring. Males also had secondary hyperthyroidism, while females had only higher T4. Since brown adipose tissue (BAT) hypofunction is related to obesity, here we tested the hypothesis that higher levels of thyroid hormones are not functional in BAT, suggesting a lower metabolic rate. We evaluated autonomic nerve activity in BAT and its function in adult rats that were exposed to tobacco smoke during lactation. At birth, litters were adjusted to 3 male and 3 female pups/litter. From postnatal day (PND) 3 to 21, Wistar lactating rats and their pups were divided into SE group, smoke-exposed in a cigarette smoking machine (4 times/day) and C group, exposed to filtered air. Offspring were sacrificed at PND180. Adult SE rats of both genders had lower interscapular BAT autonomic nervous system activity, with higher BAT mass but no change in morphology. BAT UCP1 and CPT1a protein levels were decreased in the SE groups of both genders. Male SE rats had lower β3-AR, TRα1, and TRβ1 expression while females showed lower PGC1α expression. BAT Dio2 mRNA and hypothalamic POMC and MC4R levels were similar between groups. Hypothalamic pAMPK level was higher in SE males and lower in SE females. Thus, neonatal cigarette smoke exposure induces lower BAT thermogenic capacity, which can be obesogenic at adulthood.
Subject(s)


Full text: Available Collection: International databases Health context: SDG3 - Health and Well-Being Health problem: Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil Database: LILACS Main subject: Sympathetic Nervous System / Tobacco Smoke Pollution / Adipose Tissue, Brown / Biomarkers / Thermogenesis Type of study: Prognostic study / Risk factors Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade do Estado do Rio de Janeiro/BR

Full text: Available Collection: International databases Health context: SDG3 - Health and Well-Being Health problem: Target 3.9: Reduce the amount of deaths produced by dangerous chemicals and the pollution of the air, water and soil Database: LILACS Main subject: Sympathetic Nervous System / Tobacco Smoke Pollution / Adipose Tissue, Brown / Biomarkers / Thermogenesis Type of study: Prognostic study / Risk factors Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2018 Document type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade do Estado do Rio de Janeiro/BR
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