Cytotoxic activity in cutaneous leishmaniasis
Mem. Inst. Oswaldo Cruz
; 112(11): 733-740, Nov. 2017. tab, graf
Article
in En
| LILACS
| ID: biblio-894850
Responsible library:
BR1.1
ABSTRACT
Cutaneous leishmaniasis (CL) is a chronic disease caused by species of the protozoan Leishmania and characterised by the presence of ulcerated skin lesions. Both parasite and host factors affect the clinical presentation of the disease. The development of skin ulcers in CL is associated with an inflammatory response mediated by cells that control parasite growth but also contribute to pathogenesis. CD8+ T cells contribute to deleterious inflammatory responses in patients with CL through cytotoxic mechanisms. In addition, natural killer cells also limit Leishmania infections by production of interferon-γ and cytotoxicity. In this review, we focus on studies of cytotoxicity in CL and its contribution to the pathogenesis of this disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Killer Cells, Natural
/
T-Lymphocytes, Cytotoxic
/
Leishmaniasis, Cutaneous
/
CD8-Positive T-Lymphocytes
/
Cytotoxicity, Immunologic
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
MEDICINA TROPICAL
/
PARASITOLOGIA
Year:
2017
Document type:
Article
/
Project document
Affiliation country:
Brazil
Country of publication:
Brazil