Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
Hematol., Transfus. Cell Ther. (Impr.)
; 40(1): 12-17, Jan.-Mar. 2018. tab, ilus
Article
in English
| LILACS
| ID: biblio-953795
Responsible library:
BR408.1
Localization: BR408.1
ABSTRACT
Abstract Background:
Several studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent.Objective:
The purpose of this study was to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil.Method:
H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment.Results:
The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.Conclusions:
H. pylori eradication therapy showed relatively low platelet recovery rates, comparable with previous studies from southeastern Brazil. The effect of H. pylori eradication on platelet counts remained after one year of follow-up suggesting that treating H. pylori infection might be worthwhile in a subset of chronic idiopathic thrombocytopenic purpura patients.
Full text:
Available
Collection:
International databases
Database:
LILACS
Main subject:
Platelet Count
/
Blood Platelets
/
Helicobacter pylori
/
Purpura, Thrombocytopenic, Idiopathic
Type of study:
Risk factors
Limits:
Aged
/
Aged, 80 and over
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Hematol., Transfus. Cell Ther. (Impr.)
Journal subject:
Hematologia
/
TransfusÆo de Sangue
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Hematologia e Hemoterapia do Ceará/BR
/
Universidade Federal do Ceará/BR