Role of moxifloxacin-dexamethasone in cardiac histomorphometric findings among Wistar rats from infected mothers
Acta cir. bras
; 33(9): 744-752, Sept. 2018. tab, graf
Article
in En
| LILACS
| ID: biblio-973504
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To investigate cardiac changes in young rats, whose mothers underwent autogenic fecal peritonitis, during organogenesis phase and to evaluate the role of intravenous administration of moxifloxacin and dexamethasone in preventing infection-related cardiac changes.Methods:
A prospective histomorphometric study was performed on 29 hearts of Wistar four-month old rats. Animals were divided into three groups Negative Control Group (NCG) included 9 subjects from healthy mothers; Positive Control Group (PCG) included 10 subjects from mothers with fecal peritonitis (intra-abdominal injection of 10% autogenic fecal suspension in the gestational period) and did not receive any treatment; and Intervention Group (IG), with 10 animals whose infected mothers received moxifloxacin and dexamethasone treatment 24 hours after induction of fecal peritonitis.Results:
Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG.Conclusion:
Induced autogenic fecal peritonitis in pregnant Wistar rats determined myocardial changes in young rats that could be avoided by the early administration of intravenous moxifloxacin and dexamethasone.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Peritonitis
/
Dexamethasone
/
Fluoroquinolones
/
Myocardium
Type of study:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2018
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil