Descripción del uso de ertapenem en un hospital público de alta complejidad en Medellín, Colombia / Description of the use of ertapenem in a high complexity public hospital in Medellin, Colombia
Arch. med
; 18(2): 394-403, 2018/11/19.
Article
in Es
| LILACS
| ID: biblio-980676
Responsible library:
CO279.1
RESUMEN
Objetivo:
describir el uso de ertapenem y las características clínico-microbiológicas de los pacientes durante la admisión en centro de cuarto nivel de complejidad en Medellín, Colombia entre 2009 y 2012. Materiales ymétodos:
estudio descriptivo retrospectivo en pacientes que recibieron ertapenem como terapia antibiótica.Resultados:
1390 historias clínicas revisadas, 835 cumplieron criterios de selección. Ertapenem se usó un 36,9% para manejo de infecciones urinarias y 28,1% en infección intraabdominal principalmente; en 84% se realizó cultivo microbiológico y en 80% se aisló algún germen, entre ellos 42,5% E. coli, 24,3% K. pneumoniae y 5,8% P. mirabilis. Las cepas Beta Lactamasa de Espectro Extendido de E. coli y K. pneumoniae fueron 39,8% y 57% respectivamente. La susceptibilidad a ertapenem en E. coli fue de 96,6% y K. pneumoniae 94,4%.Conclusiones:
ertapenem ofrece resultados clínicos favorablesen el manejo de infecciones urinarias e intraabdominales. Es una alternativa para el manejo empírico de infecciones de origen comunitario y como terapia dirigida en infecciones hospitalarias..(AU)ABSTRACT
Objective:
to describe the use of ertapenem along with the clinical and microbiological characteristics of patients during their admission to a fourth-level health care facility in Medellin, Colombia between 2009 and 2012. Materials andMethods:
a descriptive retrospective study on patients that were given antibiotic therapy with ertapenem.Results:
1390 clinical charts were reviewed, selecting 835 according to selection criteria. Ertapenem was prescribed in 36,9% for urinary tract infections and 28,1% for intraabdominal infections; 60% of the patients were located on general wards at the time of treatment with ertapenem. Microbiological cultures were performed for 84% of patients and 80% of those were positive, with 42,5% E. coli, 24,3% K. pneumoniae and 5,8% P. mirabilis. Extended spectrum betalactamases were found in 39,8% of the E. coli and 57% K. pneumoniae strains. Susceptibility of E. coli strains to ertapenem was 96,6% and 94,4% for K. pneumoniae.Conclusions:
ertapenem offers favorable results when used for the treatment of urinary tract and intraabdominal infections. It is an alternative for empirical management of infections acquired outside the hospital setting, and and as directed therapy in hospital infections..(AU)Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Antibiotic Prophylaxis
/
Drug Control for Patient in Transit
Type of study:
Observational_studies
Limits:
Humans
Country/Region as subject:
America do sul
/
Colombia
Language:
Es
Journal:
Arch. med
Journal subject:
MEDICINA
Year:
2018
Document type:
Article
Affiliation country:
Colombia