Influence of the geometry of nanostructured hydroxyapatite and alginate composites in the initial phase of bone repair
Acta cir. bras
; 34(2): e201900203, 2019. tab, graf
Article
in En
| LILACS
| ID: biblio-989053
Responsible library:
BR1.1
ABSTRACT
Abstract Purpose:
To analyze, histomorphologically, the influence of the geometry of nanostructured hydroxyapatite and alginate (HAn/Alg) composites in the initial phase of the bone repair.Methods:
Fifteen rats were distributed to three groups MiHA - bone defect filled with HAn/Alg microspheres; GrHA - bone defect filled with HAn/Alg granules; and DV - empty bone defect; evaluated after 15 days postoperatively. The experimental surgical model was the critical bone defect, ≅8.5 mm, in rat calvaria. After euthanasia the specimens were embedded in paraffin and stained with hematoxylin and eosin, picrosirius and Masson-Goldner's trichrome.Results:
The histomorphologic analysis showed, in the MiHA, deposition of osteoid matrix within some microspheres and circumjacent to the others, near the bone edges. In GrHA, the deposition of this matrix was scarce inside and adjacent to the granules. In these two groups, chronic granulomatous inflammation was noted, more evident in GrHA. In the DV, it was observed bone neoformation restricted to the bone edges and formation of connective tissue with reduced thickness in relation to the bone edges, throughout the defect.Conclusion:
The geometry of the biomaterials was determinant in the tissue response, since the microspheres showed more favorable to the bone regeneration in relation to the granules.Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Biocompatible Materials
/
Durapatite
/
Nanostructures
/
Alginates
Limits:
Animals
Language:
En
Journal:
Acta cir. bras
Journal subject:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Year:
2019
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil