Evaluation of vitamin D relationship with type 2 diabetes and systolic blood pressure
BMJ Open Diabetes Res Care
; 4(1): 1-5, 2016.
Article
in English
| MedCarib
| ID: biblio-995712
Responsible library:
TT5
ABSTRACT
Objective:
To investigate whether relationships existamong vitamin D, type 2 diabetes mellitus (T2DM), and blood pressure in Trinidadian subjects with T2DM. Research design andmethods:
This was a case controlled study to determine if vitamin D levels were lower in patients with T2DM. After data analysis, an exploratory hypothesis of vitamin D relationship to systolic blood pressure (SBP) was developed. Plasma calcifediol (25(OH)D) concentrations were used as a measurement for vitamin D levels and were determined by ELISA. Cholesterol levels were measured by an automated dry chemistry analyzer and blood pressure was measured using an automatic blood pressure monitor.Results:
There was no significant difference ( p=0.139, n=76) in 25(OH)D levels between patients with T2DM and controls. Subjects with SBP above 130 mm Hg were 8 times more likely to have a 25(OH)D plasma concentration above 25 ng/mL (OR 7.9 (2.2 to 28.7)), and were 5 times (OR 4.7 (1.7 to 15.1)) more likely to have a 25(OH)D plasma concentration above 30 ng/mL (OR 7.5 (2.324.2)). Vitamin D levels moderately and positively correlated with SBP (rs=0.38, p=0.001).Conclusions:
There was no significant difference in the 25(OH)D levels between patients with T2DM and controls ( p=0.139). Patients with SBP under 130 mm Hg were 8 times more likely to have a vitamin D level above 25 ng/mL (OR 7.9 (2.2 to 28.7)). Further investigations are required to examine the relationship between vitamin D and SBP.
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Collection:
International databases
Database:
MedCarib
Main subject:
Trinidad and Tobago
/
Diabetes Mellitus
/
Hypertension
Country/Region as subject:
English Caribbean
/
Trinidad and Tobago
Language:
English
Journal:
BMJ Open Diabetes Res Care
Year:
2016
Document type:
Article
Institution/Affiliation country:
The University of the West Indies/TT