Utilidad de 11C-metionina PET/CT en neurooncología. / [Utility of 11C-methionine PET/CT in neuro-oncology].
Medicina (B Aires)
; 73(3): 201-6, 2013.
Article
in Es
| BINACIS
| ID: bin-133092
ABSTRACT
Positron emission tomography (PET) with 11C-methionine (11C-methionine PET/CT) is a new technique used to evaluate primary central nervous system (CNS) tumors. We describe our experience regarding the first 4 patients with glial tumors and 11C-methionine PET/CT. This is a descriptive, observational and prospective study of 4 patients between 38-50 years of age, with different gliomas (WHO classification). MRI and 11C-methionine PET/CT were performed in all cases. Case 1, gliomatosis cerebri grade II post-radiotherapy. Case 2, oligodendroglioma grade II diagnosed and treated with radiotherapy in 1993. Case 3, glioblastoma grade IV post-radiotherapy + temozolomide. Case 4, anaplastic oligoastrocytoma grade III post-radiotherapy + temozolomide. The pattern of 11C-methionine uptake compared with MRI showed tumor progression in cases 1, 3 and 4, and in case 2 showed uptake although the final diagnosis was pseudoprogression. Unlike 18fluordeoxiglucose PET/TC, 11C-methionine uptake in normal brain tissue and pseudoprogression is low, and gliomas are displayed as metabolically active areas. The 11C-methionine PET/CT provided valuable information on the tumoral behavior and extension, although in one case presented did not differentiate tumor progression from pseudoprogression. 11C-methionine PET/CT could be a useful tool in the study and follow-up to patients with gliomas.
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Collection:
06-national
/
AR
Database:
BINACIS
Main subject:
Brain Neoplasms
/
Radiopharmaceuticals
/
Positron-Emission Tomography
/
Multimodal Imaging
/
Glioma
/
Methionine
Type of study:
Observational_studies
Language:
Es
Journal:
Medicina (B Aires)
Year:
2013
Document type:
Article