Oral Zinc Sulphate Supplementation for Six Months in SCA2 Patients: A Randomized, Double-Blind, Placebo-Controlled Trial
Nat. hum
; 36(10)oct. 2011. tab, graf
Article
in English
| CUMED
| ID: cum-60088
Responsible library:
CU424.1
ABSTRACT
Cuban patients with Spinocerebellar Ataxia type 2 (SCA2) have reduced concentrations of zinc in serum and cerebrospinal fluid (CSF). To assess the effect and safety of zinc supplementation, 36 Cuban SCA2 patients were randomly assigned to receive daily either 50 mg ZnSO4 or placebo, together with neurorehabilitation therapy in a randomized, double-blind, placebo-controlled clinical trial during 6 months. Outcome measures included the changes of zinc levels in CSF and serum, ataxia score, oxidative stress and saccadic eye movements. At the end of the study, the Zinc-treated group showed (i) a significant increase of the Zn levels in the CSF, (ii) mild decrease in the ataxia scale subscores for gait, posture, stance and dysdiadochocinesia (iii) reduction of lipids oxidative damage, and (iv) reduction of saccadic latency when compared with the placebo group. The treatment was safe and well tolerated by all subjects. This study demonstrated the efficacy and safety of Zn supplementation, combined with neurorehabilitation for SCA2 patients and therefore it may encourage further studies on the clinical effect of zinc supplementation in SCA2 based in the conduction of future clinical trials with higher number of subjects(AU)
Full text:
Available
Collection:
National databases
/
Cuba
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 9: Noncommunicable diseases and mental health
Database:
CUMED
Main subject:
Placebos
/
Zinc Sulfate
/
Dietary Supplements
/
Spinocerebellar Ataxias
Type of study:
Controlled clinical trial
Limits:
Adolescent
/
Adult
/
Humans
Language:
English
Journal:
Nat. hum
Year:
2011
Document type:
Article
Institution/Affiliation country:
Centro Para la Investigación y Rehabilitación de las Ataxias Hereditarias/Cuba
/
Centro Para la Producción de Animales de Laboratorio/Cuba
/
Centro de Desarrollo e Investigación de Medicamentos/Cuba
/
Centro para la Investigación y Rehabilitación de las Ataxias Hereditarias/Cuba
/
Hospital Clínico Quirúrgico Lucia Iñiguez Landín/Cuba
/
Hospital Provincial de Medicina Natural y Tradicional/Cuba
/
Instituto Nacional de Salud del Trabajo/Cuba