Modelo experimental de fotoenvejecimiento cutáneo por radiación ultravioleta A / Experimental model of UVA-induced cutaneous photoageing
Rev. esp. patol
; 40(2): 103-108, abr.-jun. 2007. ilus
Article
in Es
| IBECS
| ID: ibc-057505
Responsible library:
ES1.1
Localization: ES1.1 - BNCS
RESUMEN
Antecedentes La piel puede sufrir, además del envejecimiento cronológico, el fotoenvejecimiento, secundario a las radiaciones ultravioletas, las cuales se consideran el carcinógeno ambiental más potente. Material y métodos:
Hemos utilizado 32 ratones Swiss en 4 grupos I. control; II. TPA (102 sesiones); III. UVA (102 sesiones, 120 minutos/sesión); IV. TPA y UVA (32 sesiones, 120 minutos/sesión). Al final realizamos la necropsia. La piel del lomo y orejas fueron incluidas en parafina por el método habitual, seccionadas a 5 μm y teñidas con H.E. Valoramos diversos criterios histológicos epidérmicos y dérmicos (+, ++ o +++), por dos observadores distintos.Resultados:
Hemos establecido un modelo de fotoenvejecimiento en los dos grupos tratados con UVA que presentaban lesiones de displasia moderada a severa en el grupo irradiado con UVA y carcinomas invasores en el grupo con UVA y TPA, mientras que en el grupo de TPA sólo observamos múltiples áreas de hiperplasia epitelial.Conclusiones:
La exposición crónica a UVA asociada al promotor tumoral TPA ha desarrollado un modelo de fotocarcinogénesis cutánea en ratones SwissABSTRACT
Introduction:
Chronological ageing aside, skin may also experience photoageing as a result of exposure to ultraviolet radiation, considered to be the most potent environmental carcinogen. Materials andMethods:
32 Swiss mice (divided into 4 groups) were treated as follows I (Control); II (TPA 102 sessions); III (UVA 102 sessions at 120 minutes/session); IV (TPA & UVA 32 sessions at 120 minutes/session). Finally, necropsies were performed. The skin from the back and ears was included in paraffin via the usual method, sectioned at 5 μm and stained using H-E. Diverse dermal and epidermal histological criteria were evaluated (+, ++, +++), by two different observers.Results:
A model for photoageing was established for both groups treated with UVA, which displayed moderate to severe dysplasia in the case of those treated with UVA alone and invasive carcinoma in the case of those treated with UVA and TPA, whilst only (multiple) areas of epithelial hyperplasia were observed in the group treated with TPA alone.Conclusions:
Chronic exposure to UVA in conjunction with the tumour promoter TPA has provided a model for cutaneous photocarcinogenesis in Swiss mice
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Ultraviolet Rays
/
Skin Aging
/
Disease Models, Animal
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Es
Journal:
Rev. esp. patol
Year:
2007
Document type:
Article