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Evaluation of the Sensititre Yeast One microdilution method for susceptibility testing of Candida species to anidulafungin, caspofungin, and micafungin
García-Agudo, Lidia; García-Martos, Pedro; Martos-Cañadas, Jorge; Aznar-Marín, Pilar; Marín-Casanova, Pilar; Rodríguez-Iglesias, Manuel.
Affiliation
  • García-Agudo, Lidia; Hospital Universitario Puerta del Mar. Cádiz. España
  • García-Martos, Pedro; Hospital Universitario Puerta del Mar. Cádiz. España
  • Martos-Cañadas, Jorge; Hospital Universitario Puerta del Mar. Cádiz. España
  • Aznar-Marín, Pilar; Hospital Universitario Puerta del Mar. Cádiz. España
  • Marín-Casanova, Pilar; Hospital Universitario Puerta del Mar. Cádiz. España
  • Rodríguez-Iglesias, Manuel; Hospital Universitario Puerta del Mar. Cádiz. España
Rev. esp. quimioter ; 25(4): 256-260, dic. 2012. tab
Article in English | IBECS | ID: ibc-108006
Responsible library: ES1.1
Localization: BNCS
RESUMEN
Introducción. Las equinocandinas representan un nuevo grupo de antifúngicos con gran actividad frente a especies de Candida. El propósito de este estudio fue evaluar el método Sensititre Yeast One para determinar la actividad in vitro de anidulafungina, micafungina y caspofungina frente a especies de Candida aisladas de muestras clínicas. Métodos. Un total de 131 cepas de Candida identificadas como 42 C. albicans, 36 C. glabrata, 21 C. parapsilosis, 12 C. tropicalis, 10 C. krusei, 3 C. guilliermondii, 2 C. famata, 3 C. kefyr, 1 C. lusitaniae, 1 C. zeylanoides y 1 C. lipolytica, fueron ensayadas mediante el método colorimétrico de microdilución Sensititre Yeast One. Se consideraron sensibles las cepas inhibidas por concentraciones <=2 mg/L de anidulafungina, caspofungina o micafungina. Resultados. El 80,1% de las cepas fueron inhibidas por concentraciones <=0,25 mg/L de anidulafungina y micafungina. La actividad de caspofungina fue ligeramente inferior (78,6% de las cepas inhibidas por concentraciones <=0,25 mg/L). El 96,9% de las cepas resultaron sensibles frente a las tres equinocandinas. Dos cepas de C. parapsilosis (9,5%), 1 de C. guilliermondii y 2 de C. famata no mostraron sensibilidad a una o más equinocandinas. Conclusiones. En nuestra serie, anidulafungina, micafungina y caspofungina fueron efectivas frente a C. albicans, C. glabrata, C. tropicalis, C. krusei, C. kefyr, C. lusitaniae y C. lipolytica. El 96,9% de las cepas fueron sensibles a las tres equinocandinas. Se puede afirmar que las equinocandinas tienen una excelente actividad frente a las especies de Candida más frecuentes en infecciones humanas, excepto Candida parapsilosis(AU)
ABSTRACT
Introduction. Echinocandins represent a new antifungal group with potent activity against Candida species. The purpose of our study was to evaluate the utility of the Sensititre Yeast One method to determine the in vitro activity of anidulafungin, micafungin, and caspofungin against Candida species isolated from clinical specimens. Methods. A total of 131 Candida strains were tested using Sensititre Yeast One colorimetric microdilution method. They belonged to the following species 42 C. albicans, 36 C. glabrata, 21 C. parapsilosis, 12 C. tropicalis, 10 C. krusei, 3 C. guilliermondii, 2 C. famata, 3 C. kefyr, 1 C. lusitaniae, 1 C. zeylanoides, and 1 C. lipolytica. For being considered susceptible the strains had to be inhibited by concentrations <=2 mg/L of anidulafungin, caspofungin or micafungin. Results. The 80.1% of the strains tested were inhibited by concentrations <=0.25 mg/L of anidulafungin and micafungin. The activity of caspofungin was slightly lower (78.6% of strains inhibited by concentrations <=0.25 mg/L). The 96.9% of strains turned out susceptible to concentrations <=2 mg/L against the three echinocandins. Two strains of C. parapsilosis (9.5%), one of C. guilliermondii, and two of C. famata showed non-susceptible to one or more echinocandins. Conclusions. In our series, anidulafungin, micafungin, and caspofungin were effective against C. albicans, C. glabrata, C. tropicalis, C. krusei, C. kefyr, C. lusitaniae and C. lipolytica. The 96.9% of strains were susceptible to all three echinocandins. Thus, echinocandins are proved to exhibit excellent activity to the Candida species most frequently involved in human infections, except Candida parapsilosis(AU)
Subject(s)
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Collection: National databases / Spain Database: IBECS Main subject: Candida / Microbial Sensitivity Tests / Sensitivity and Specificity / Dilution / Echinocandins Type of study: Diagnostic study Language: English Journal: Rev. esp. quimioter Year: 2012 Document type: Article Institution/Affiliation country: Hospital Universitario Puerta del Mar/España
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Collection: National databases / Spain Database: IBECS Main subject: Candida / Microbial Sensitivity Tests / Sensitivity and Specificity / Dilution / Echinocandins Type of study: Diagnostic study Language: English Journal: Rev. esp. quimioter Year: 2012 Document type: Article Institution/Affiliation country: Hospital Universitario Puerta del Mar/España
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