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Changes in the inmunne cell p opulation and cell proliferation in peripheral blood after gemcitabine-based chemotherapy for pancreatic cancer
Homma, Y; Taniguchi, K; Nakazawa, M; Matsuyama, R; Mori, R; Takeda, K; Ichikawa, Y; Tanaka, K; Endo, I.
Affiliation
  • Homma, Y; Yokohama City University. School of Medicine. Yokohama. Japan
  • Taniguchi, K; Yokohama City University. School of Medicine. Yokohama. Japan
  • Nakazawa, M; Yokohama City University. School of Medicine. Yokohama. Japan
  • Matsuyama, R; Yokohama City University. School of Medicine. Yokohama. Japan
  • Mori, R; Yokohama City University. School of Medicine. Yokohama. Japan
  • Takeda, K; Yokohama City University. School of Medicine. Yokohama. Japan
  • Ichikawa, Y; Yokohama City University. School of Medicine. Yokohama. Japan
  • Tanaka, K; Yokohama City University. School of Medicine. Yokohama. Japan
  • Endo, I; Yokohama City University. School of Medicine. Yokohama. Japan
Clin. transl. oncol. (Print) ; 16(3): 330-335, mar. 2014.
Article in En | IBECS | ID: ibc-127742
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
PURPOSE: Regulatory T cells (Tregs) play a role in the immunosuppressive state in pancreatic cancer patients. We aimed to evaluate the changes of immune cells population including Tregs caused by gemcitabine (GEM)-based chemotherapy. METHODS: Fifty-three patients with pancreatic cancer were enrolled in this study, of which 32 received GEM- based chemotherapy. Blood samples were collected before and at least 2 weeks after the last dose of chemotherapy. The peripheral blood mononuclear cells (PBMCs) were subjected to flow cytometry analysis after labeling with anti-CD4, anti-CD25, and anti-Foxp3 antibodies. Other lymphocytes and NK cell markers were also measured. The proliferative capacity of PBMCs stimulated with anti-CD3 was analyzed using H(3) thymidine. RESULTS: The percentage and number of Tregs were significantly decreased after chemotherapy (p = 0.032, p = 0.003, respectively). The other immune cells and the proliferative capacity did not change. CONCLUSION: This study showed that GEM-based chemotherapy produced an immunomodulatory effect via the depletion of Tregs (AU)
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Collection: 06-national / ES Database: IBECS Main subject: Pancreatic Neoplasms / T-Lymphocytes, Regulatory / Cell Proliferation Limits: Adult / Aged / Female / Humans / Male Language: En Journal: Clin. transl. oncol. (Print) Year: 2014 Document type: Article
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Collection: 06-national / ES Database: IBECS Main subject: Pancreatic Neoplasms / T-Lymphocytes, Regulatory / Cell Proliferation Limits: Adult / Aged / Female / Humans / Male Language: En Journal: Clin. transl. oncol. (Print) Year: 2014 Document type: Article