Pentoxifylline during steroid window phase at induction to remission increases apoptosis in childhood with acute lymphoblastic leukemia
Clin. transl. oncol. (Print)
; 18(4): 369-374, abr. 2016. tab, graf
Article
in En
| IBECS
| ID: ibc-150450
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Purpose: Pentoxifylline (PTX) has been shown to increase chemotherapy-induced apoptosis. A clinical trial was developed to evaluate the effect of the addition of PTX to the induction steroid window phase in children with acute lymphoblastic leukemia (ALL). Methods: Thirty-two children were enrolled on this study. Children with a new diagnosis of ALL were randomly assigned to receive prednisone (PRD) 40 mg/m2/day only during the 7-day treatment pre-phase (PRD group, 11 patients) or to receive PRD with PTX (10 mg/kg/day) (PTX group, 11 patients); the control group included children with normal bone marrow (10 patients). Bone marrow aspiration (BMA) was performed at diagnosis (day -7) in all groups, and at day 0 (end of PRD window) for patients with ALL (PRD and PTX groups). Apoptosis was evaluated by flow cytometry (FC) using Annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI) stains. Statistical analysis was performed using the MannWhitney U test. Results: Apoptotic index at day -7 was similar in all groups. However, at day 0 post-treatment, apoptosis was significantly higher in the PTX group than in the PRD group (p < 0.001). There were no serious adverse effects associated with PTX. Conclusions: PTX potentiates blast apoptosis induced by PRD in children with ALL during steroid window phase (AU)
RESUMEN
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Pentoxifylline
/
Bone Marrow Cells
/
Prednisone
/
Fluorescein-5-isothiocyanate
/
Apoptosis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Clinical_trials
/
Evaluation_studies
Limits:
Adolescent
/
Child
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Child, preschool
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Female
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Clin. transl. oncol. (Print)
Year:
2016
Document type:
Article