Accurate cut-offs for predicting endoscopic activity and mucosal healing in Crohns disease with fecal calprotectin
Rev. esp. enferm. dig
; 109(2): 130-136, feb. 2017. tab, ilus
Article
in En
| IBECS
| ID: ibc-159856
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
Fecal biomarkers, especially fecal calprotectin, are useful for predicting endoscopic activity in Crohns disease; however, the cut-off point remains unclear. The aim of this paper was to analyze whether faecal calprotectin and M2 pyruvate kinase are good tools for generating highly accurate scores for the prediction of the state of endoscopic activity and mucosal healing.Methods:
The simple endoscopic score for Crohns disease and the Crohns disease activity index was calculated for 71 patients diagnosed with Crohns. Fecal calprotectin and M2-PK were measured by the enzyme-linked immunosorbent assay test.Results:
A fecal calprotectin cut-off concentration of ≥ 170 μg/g (sensitivity 77.6%, specificity 95.5% and likelihood ratio +17.06) predicts a high probability of endoscopic activity, and a fecal calprotectin cut-off of ≤ 71 μg/g (sensitivity 95.9%, specificity 52.3% and likelihood ratio -0.08) predicts a high probability of mucosal healing. Three clinical groups were identified according to the data obtained endoscopic activity (calprotectin ≥ 170), mucosal healing (calprotectin ≤ 71) and uncertainty (71 > calprotectin < 170), with significant differences in endoscopic values (F = 26.407, p < 0.01). Clinical activity or remission modified the probabilities of presenting endoscopic activity (100% vs 89%) or mucosal healing (75% vs 87%) in the diagnostic scores generated. M2-PK was insufficiently accurate to determine scores.Conclusions:
The highly accurate scores for fecal calprotectin provide a useful tool for interpreting the probabilities of presenting endoscopic activity or mucosal healing, and are valuable in the specific clinical context (AU)RESUMEN
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Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Crohn Disease
/
Colectomy
/
Endoscopy
/
Biomarkers, Pharmacological
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Rev. esp. enferm. dig
Year:
2017
Document type:
Article