Air pollution and its relationship to lung function among adolescents from Taubate, São Paulo, Brazil
Allergol. immunopatol
; 46(2): 160-166, mar.-abr. 2018. tab, graf
Article
in En
| IBECS
| ID: ibc-172175
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background:
This paper sought to evaluate individual exposure to air pollution by quantifying the carbon in alveolar macrophages (AMs) and its relationship to lung function. We also examined the proximity of participants' residences to the Presidente Dutra highway (PDH) in adolescents with asthma from Taubaté, São Paulo, Brazil.Methods:
This descriptive study examined fifty 13- to 14-year-old adolescents with asthma identified by the International Study of Asthma and Allergies in Childhood (ISAAC) in Taubaté. These adolescents underwent spirometry and sputum induction via the inhalation of 3% hypertonic saline (HSS). Sputum was collected after each nebulisation, and forced expiratory flow in one second (FEV1) was measured. The collected sputum was stored and transported to the laboratory; it was then processed and analysed for ultrafine particles (≤100 nm). This analysis was correlated with the residence location and FEV1 of each adolescent.Results:
A total of 39 adolescents completed the study. The comparison of the carbon fraction within macrophages (CA/MA) showed no differences according to residence in relation to the PDH (p=0.758). After adjustment, a mixed linear model with FEV1 as the dependent variable and CA/MA, location, and evaluation condition as the predictors found that the interactions among the variables were not significant.Conclusions:
T he amount of carbon present within the AMs of adolescents with asthma was not correlated with either lung function or residence location. Evaluations of the topograghy and local climatic conditions in Taubaté should be considered in future studies (AU)RESUMEN
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Asthma
/
Air Pollution
/
Particulate Matter
/
Soot
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Humans
Country/Region as subject:
America do sul
/
Brasil
Language:
En
Journal:
Allergol. immunopatol
Year:
2018
Document type:
Article