El incremento de la grasa epicárdica en mujeres se asocia a riesgo trombótico / An increase in epicardial fat in women is associated with thrombotic risk
Clín. investig. arterioscler. (Ed. impr.)
; 30(3): 112-117, mayo-jun. 2018. ilus, tab, graf
Article
in Es
| IBECS
| ID: ibc-175425
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
Introducción: En pacientes con enfermedad coronaria se ha observado una disminución de la actividad fibrinolítica y aumento del grosor del tejido adiposo epicárdico. El objetivo del estudio fue determinar la relación entre la grasa epicárdica y la actividad fibrinolítica, midiendo la concentración del inhibidor del activador del plasminógeno tipo-1 (PAI-1). Métodos: Estudio transversal que incluyó a 56 mujeres aparentemente sanas, con edad de 45-60 años. A las participantes se les realizaron mediciones antropométricas y bioquímicas, la actividad fibrinolítica se determinó midiendo PAI-1 por la técnica de ELISA. El grosor epicárdico se evaluó por ecocardiografía transtorácica. Resultados: La concentración de PAI-1 se asoció directamente con el grosor del tejido adiposo epicárdico (r = .475, p = .001), glucosa, triglicéridos, resistencia a la insulina, IMC, tejido adiposo visceral y grasa corporal total. El análisis de regresión multivariado indicó que la grasa epicárdica predice en forma independiente el valor de PAI-1. Conclusiones: Las mujeres con incremento de tejido adiposo epicárdico muestran menor actividad fibrinolítica por presentar niveles aumentados de PAI-1 y, en consecuencia, un posible mayor riesgo trombótico
ABSTRACT
Introduction: A decrease in fibrinolytic activity and an increase in the thickness of the epicardial adipose tissue have been observed in patients with coronary artery disease. The aim of this study was to determine the association between epicardial adipose tissue and fibrinolytic activity by measuring the concentration of plasminogen activator inhibitor-1 (PAI-1). Methods: A cross-sectional study was conducted on 56 apparently healthy women aged 45 to 60 years. Anthropometric measurements and biochemical determinations were performed on all participants. The fibrinolytic activity was determined by measuring PAI-1 by ELISA. Epicardial thickness was assessed by transthoracic echocardiography. Results: The concentration of PAI-1 was directly associated with the thickness of the epicardial adipose tissue (r = 0.475, P = .001), body mass index (BMI), visceral adipose tissue, insulin resistance, glucose, and HDL-cholesterol. The multivariate regression analysis indicated that epicardial fat independently predicts the concentrations of PAI-1. Conclusions: Women with thicker epicardial adipose tissue have reduced fibrinolytic activity, and consequently greater thrombotic risk
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Pericardium
/
Plasminogen Inactivators
/
Adipose Tissue
/
Fibrinolysis
Type of study:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
Es
Journal:
Clín. investig. arterioscler. (Ed. impr.)
Year:
2018
Document type:
Article