Prevalence and progression of chronic kidney disease after liver transplant: a prospective, real-life, observational, two-year multicenter study
Rev. esp. enferm. dig
; 110(9): 538-543, sept. 2018. tab, graf
Article
in English
| IBECS
| ID: ibc-177773
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Introduction:
chronic kidney disease is a frequent complication after liver transplantation. The use of calcineurin inhibitors is one of the causes of this complication. Current immunsuppression regimens that reduce the use of calcineurin inhibitors may be associated with an improved preservation of renal function.Objective:
the study aimed to assess the evolution of renal function after liver transplantation in the current routine clinical practice.Methods:
an observational, prospective, multicenter study in adult liver transplant recipients was performed. Two hundred and thirty patients with a good renal function before transplantation were assessed six months post-transplantation (baseline) and every six months until month 30.Results:
at baseline, 32% of the patients had a reduction in the glomerular filtration rate below < 60 ml/min/1.73 m2. The mean glomerular filtration rate increased from 72.3 to 75.6 ml/min/1.73 m2 at baseline and month 30 respectively (p < 0.01). The mean serum creatinine levels (mg/dl) decreased from 1.13 to 1.09 (p < 0.01). The percentage of patients with stage 3 chronic kidney disease decreased from 31.7% to 26.4%, whereas the percentage of patients with stage 4 remained unchanged (0.4% at baseline and 0.5% at month 30). No patients progressed to end-stage kidney disease that required dialysis or renal transplantation.Conclusion:
in the routine clinical practice, a moderate deterioration of renal function is frequent after liver transplantation. However, advanced chronic kidney disease is infrequent in patients with a good pre-transplant renal functionRESUMEN
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Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Liver Transplantation
/
Renal Insufficiency, Chronic
/
Graft Survival
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2018
Document type:
Article
Institution/Affiliation country:
Clínica Universidad de Navarra/Spain
/
Digestive and Liver Disease Biomedical Research Network (CIBERehd)/Spain
/
Hospital Clínico Universitario Lozano Blesa/Spain
/
Hospital Cruces/Spain
/
Hospital Infanta Cristina/Spain
/
Hospital Regional Universitario Carlos Haya/Spain
/
Hospital Universitario A Coruña/Spain
/
Hospital Universitario Central de Asturias/Spain
/
Hospital Universitario Río Hortega/Spain
/
Hospital Universitario de Bellvitge/Spain