Agaricus bisporus supplementation reduces high-fat diet-induced body weight gain and fatty liver development
J. physiol. biochem
; 74(4): 635-646, nov. 2018. tab, graf, ilus
Article
in En
| IBECS
| ID: ibc-179041
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Obesity is a global epidemic characterized not only by excessive fat deposition but also by important complications such as nonalcoholic liver steatosis. Beneficial antiobesogenic effects have been described for some mushrooms. The current study aimed to demonstrate the protective effect of Agaricus bisporus (AB) supplementation against the metabolic alterations induced by high-fat-diet (HFD) feeding. Eight-week-old C57BL/6J mice were fed for 10 weeks with one of the following diets: (1) control diet (n = 7), (2) HFD (n = 7), (3) HFD supplemented with 5% AB (n = 9), and (4) HFD supplemented with 10% AB (n = 9). A pair-fed group was also included for the 10% AB group (n = 6). The impact of AB supplementation on food intake, body weight gain, and liver and fat pad weights was examined. Biochemical, histological, and molecular parameters were also analyzed. Dietary supplementation with 10% AB reduced the HFD-induced increase in body, epididymal, and mesenteric fat weights (p < 0.01, p < 0.05, and p < 0.05, respectively). Supplementation with AB also reduced liver damage in a dose-dependent manner (p < 0.01 and p < 0.001). This effect was confirmed by histological analysis that showed that liver steatosis was markedly reduced in mice fed with AB. The beneficial properties of 10% AB supplementation appear to be mediated through a decrease in food intake and via stimulation of mesenteric and hepatic free-fatty acid beta-oxidation, along with a decrease in epidydimal and hepatic expression of CD36. In conclusion, supplementation with AB prevents excessive body weight gain and liver steatosis induced by HFD consumption
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Biological Products
/
Agaricus
/
Anti-Obesity Agents
/
Dietary Supplements
/
Non-alcoholic Fatty Liver Disease
/
Lipotropic Agents
/
Obesity
Limits:
Animals
Language:
En
Journal:
J. physiol. biochem
Year:
2018
Document type:
Article