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Altered expression of COX-2 and TNF-alfa in patients with hepatocellular carcinoma
Alves, Andressa de Freitas; Baldissera, Vanessa Dido; Chiela, Eduardo Cremonese Filippi; Cerski, Carlos Thadeu Schmidt; Fontes, Paulo Roberto Ott; Fernandes, Marilda da Cruz; Porawski, Marilene; Giovenardi, Márcia.
Affiliation
  • Alves, Andressa de Freitas; Universidade Federal de Ciências da Saúde de Porto Alegre. Health Sciences Postgraduate Program. Porto Alegre. Brazil
  • Baldissera, Vanessa Dido; Universidade Federal de Ciências da Saúde de Porto Alegre. Health Sciences Postgraduate Program. Porto Alegre. Brazil
  • Chiela, Eduardo Cremonese Filippi; Hospital de Clínicas de Porto Alegre. Gastroenterology Postgraduate Program. Porto Alegre. Brazil
  • Cerski, Carlos Thadeu Schmidt; Universidade Federal do Rio Grande do Sul. Department of Pathology. Porto Alegre. Brazil
  • Fontes, Paulo Roberto Ott; Universidade Federal de Ciências da Saúde de Porto Alegre. Medicine Postgraduate Program Hepatology. Porto Alegre. Brazil
  • Fernandes, Marilda da Cruz; Universidade Federal de Ciências da Saúde de Porto Alegre. Pathology Postgraduate Program. Porto Alegre. Brazil
  • Porawski, Marilene; Universidade Federal de Ciências da Saúde de Porto Alegre. Biosciences Postgraduate Program. Porto Alegre. Brazil
  • Giovenardi, Márcia; Universidade Federal de Ciências da Saúde de Porto Alegre. Biosciences Postgraduate Program. Porto Alegre. Brazil
Rev. esp. enferm. dig ; 111(5): 364-370, mayo 2019. ilus, tab, graf
Article in English | IBECS | ID: ibc-189989
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Background and

aim:

hepatocellular carcinoma is a type of cancer related with inflammation, as 90% of cases develop in a chronic inflammation condition. Excess inflammation can affect tissue homeostasis. Cytokines and inflammatory mediators are immunological components that can influence the functioning of cells and tissues. In addition, the estrogen receptor appears to play an important role in hepatocarcinogenesis. The aim of the study was to evaluate the expression of inflammatory markers and ER in patients with hepatocellular carcinoma.

Methods:

data from 143 patients of ISCMPA were analyzed. Immunohistochemistry was performed of cyclooxygenase-2 enzyme (COX-2), nuclear factor kappa B (NF-κB), tumor necrosis factor alpha (TNF-alfa) and ER in paraffin-embedded hepatic tissue. The percentage of the stained area, intensity of staining and of the number of ER positive nuclei were evaluated using the ImageJ 1.50 software. Results and

conclusion:

there was a significant difference between the groups in terms of the percentage of marked area (p = 0.040) for COX-2 and the intensity of staining of TNF-alfa (p = 0.030). No significant differences were observed in any of other parameters evaluated. In conclusion, COX-2 and TNF-alfa are possible markers that should be further studied to determine their immunohistochemical profile and role in HCC development
RESUMEN
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Collection: National databases / Spain Database: IBECS Main subject: Tumor Necrosis Factor-alpha / Carcinoma, Hepatocellular / Cyclooxygenase 2 / Liver Neoplasms Limits: Female / Humans / Male Language: English Journal: Rev. esp. enferm. dig Year: 2019 Document type: Article Institution/Affiliation country: Hospital de Clínicas de Porto Alegre/Brazil / Universidade Federal de Ciências da Saúde de Porto Alegre/Brazil / Universidade Federal do Rio Grande do Sul/Brazil
Search on Google
Add to My VHL
Print
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Collection: National databases / Spain Database: IBECS Main subject: Tumor Necrosis Factor-alpha / Carcinoma, Hepatocellular / Cyclooxygenase 2 / Liver Neoplasms Limits: Female / Humans / Male Language: English Journal: Rev. esp. enferm. dig Year: 2019 Document type: Article Institution/Affiliation country: Hospital de Clínicas de Porto Alegre/Brazil / Universidade Federal de Ciências da Saúde de Porto Alegre/Brazil / Universidade Federal do Rio Grande do Sul/Brazil