Plasma cell dyscrasia behavior in a referral hospital in southern Colombia: younger, clinically and paraclinically worse than reported
Galicia clin
; 81(4): 102-107, dic. 2020. tab, graf
Article
in English
| IBECS
| ID: ibc-201651
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
OBJECTIVES:
Plasma cell dyscrasias are diseases characterized by clonal proliferation and accumulation of cells producing monoclonal immunoglobulins. These diseases have not been studied in our region and we don't know if their behavior is similar to that reported in the literature. That's why we evaluated multiple characteristics in southern Colombia.METHODS:
analytical cross-sectional study of patients with confirmed diagnosis of a plasma cell dyscrasias were included.RESULTS:
60 patients included in our study, 65% were men, with an average age of 58.8 years (CI 96% 55.8 - 61.93). Bone pain was the most frequent symptom (88%). The most frequent dyscrasia was multiple myeloma and in these patients we found a high percentage of hemoglobin less than 10 mg/dl, creatinine greater than 2 mg/dl and serum calcium higher than 11 mg/dl (77%, 38% and 37 %, respectively). Half of the patients had a time course of symptoms greater than 4 months and 43% had plasma cells in bone marrow greater than 60%. 65% of patients had elevated levels of serum B2-microglobulin (> 5.5 mg/L) and in-hospital mortality was 15%. We found a statistically significant association between mortality and gender (PR 6.5) and between mortality and hemoglobin (p = 0.039).CONCLUSION:
Patients with plasma cell dyscrasia in southern Colombia are younger, consult late, in an advanced stage of their disease, with greater renal damage, hypercalcemia and anemia than reported in the literature, also a high tumor burden due to high plasma cell infiltration into bone marrow and high values of serum B2-microglobulinRESUMEN
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Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Paraproteinemias
/
Monoclonal Gammopathy of Undetermined Significance
/
Multiple Myeloma
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Galicia clin
Year:
2020
Document type:
Article
Institution/Affiliation country:
North Side Hospital/United States
/
University Hospital Hernando Moncaleano Perdomo/Colombia