Exclusive 3D-brachytherapy as a good option for stage-I inoperable endometrial cancer: a retrospective analysis in the gynaecological cancer GEC-ESTRO Working Group
Clin. transl. oncol. (Print)
; 24(2): 254-265, febrero 2022.
Article
in English
| IBECS
| ID: ibc-203431
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
PurposeAnalyse outcomes of stage-I inoperable endometrial cancer (EC) patients from seven European centres treated with 3D-image-guided brachytherapy (IGBT) alone.Materials and methodsFrom 2004 to 2018, 62 patients (41 stage-IA and 21 IB) were retrospectively studied, analysing anaesthetic procedure, applicator type, BT-planning imaging, clinical target volume (CTV), BT schedule, overall daily-dose equivalent to 2 Gy (EQD2(α/β=4.5 or 3)) to the CTV(α/β=4.5) and D2 cm3(α/β=3) for organs at risk. Complications were evaluated using CTCAEv4 scores. The 2 and 5 year survival was calculated [cancer-specific survival (CSS), disease-free survival (DFS), local relapse-free survival (LRFS), loco-regional relapse-free survival (LRRFS) and distant metastasis-free survival (DMFS)]. Descriptive analysis and the KaplanMeier method were used for survival analysis.ResultsMean follow-up 32.8 months (SD 33.7). Spinal anaesthesia (38/62) followed by none (16/62) were the most common. Y-shaped Rotte applicators were used in 74% of patients. High-dose rate brachytherapy was administered in 89%. Median D90 to the CTV was 58.9 Gy (8.66144 Gy). Eight patients presented relapse four uterine, four nodal and four distant. The 2 and 5 year CSS was 93.3 and 80.5%, DFS 84.8 and 80.5%, LRFS was 93.1 and 88.7%, LRRFS was 91 and 91% and DMFS was 90.2 and 90.2%, respectively, CSS was better in stage-IA vs. IB (p = 0.043). Late vaginal and bladder G3-complication rates were 2.1%, respectively.ConclusionInoperable EC patients can be safely treated by BT with 2 and 5 year CSS of 93 and 80.5%, respectively, with even better results for IA cases. Prospective studies on 3D-IGBT are necessary to better analyse EC patient outcomes based on dose and treated volumes.
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Brachytherapy
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Endometrial Neoplasms
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Health Sciences
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2022
Document type:
Article
Institution/Affiliation country:
Henan Provincial Peoples Hospital/China
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Institute Gustave Roussy/France
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Institute of Oncology of Ljubljana/Slovenia
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Leeds Cancer Centre/UK
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Maria Sklodowska-Curie National Research Institute of Oncology/Poland
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Mount Vernon Cancer Centre/UK
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Radiation Oncology Department/The Netherlands
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Universitat de Barcelona/Spain