Glycosylation and its research progress in endometrial cancer
Clin. transl. oncol. (Print)
; 24(10): 18651880, octubre 2022. ilus, tab
Article
in En
| IBECS
| ID: ibc-207943
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Endometrial cancer (EC) is one of the most common tumors in the female reproductive system, which seriously threatens women's health, particularly in developed countries. 13% of the patients with EC have a poor prognosis due to recurrence and metastasis. Therefore, identifying good predictive biomarkers and therapeutic targets is critical to enable the early detection of metastasis and improve the prognosis. For decades, extensive studies had focused on glycans and glycoproteins in the progression of cancer. The types of glycans that are covalently attached to the polypeptide backbone, usually via nitrogen or oxygen linkages, are known as N‑glycans or O‑glycans, respectively. The degree of protein glycosylation and the aberrant changes in the carbohydrate structures have been implicated in the extent of tumorigenesis and reported to play a critical role in regulating tumor invasion, metabolism, and immunity. This review summarizes the essential biological role of glycosylation in EC, with a focus on the recent advances in glycomics and glycosylation markers, highlighting their implications in the diagnosis and treatment of EC. (AU)
Key words
Full text:
1
Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Glycosylation
/
Glycoproteins
/
Biomarkers
/
Endometrial Neoplasms
/
Glycomics
Limits:
Humans
Language:
En
Journal:
Clin. transl. oncol. (Print)
Year:
2022
Document type:
Article