Patterns of treatment failure in patients with prostate cancer treated with 76 80 radiotherapy to the prostate and seminal vesicles
Clin. transl. oncol. (Print)
; 23(3): 481-490, mar. 2021. graf
Article
in En
| IBECS
| ID: ibc-220883
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Purpose To assess the pattern of treatment failure in patients with prostate cancer (PCa) treated with radiotherapy (7680 Gy) ± hormone therapy (HT). We also evaluated the influence of treatment failure on survival outcomes. Methods Retrospective study of patients with PCa (n = 302) treated with radiotherapy (RT) ± HT at our centre between November 1999 and July 2007. The mean patient age was 70.2 years (range 5187). Distribution by NCCN risk group was low (n = 80, 26.5%), intermediate (n = 86, 28.5%), high (n = 77, 25.5%), and very high (n = 49, 16.2%). Most patients (n = 273, 90.4%) received IMRT at a dose of 7680 Gy. HT was administered in 237 patients (78.5%), in most cases (n = 167, 55.3%) for < 7 months Results Survival rates at 10 years were overall survival (OS), 64.3%; biochemical disease-free survival, 83.9%; disease-free survival, 92.5%; and metastasis-free survival (MFS), 94.3%. Biochemical failure (BF) was observed in 55 cases (18.2%), 32 of whom subsequently developed clinical recurrence metastasis (n = 17, 5.6%), local failure (n = 11, 3.6%), and regional failure (n = 4, 1.3%). The cause of death (n = 159) was intercurrent disease in 115 cases (72.3%), second cancer in 27 (17.0%), and PCa in 17 (10.7%). Biochemical failure-free survival ≤ 24 months was significantly associated with worse OS and MFS (p = 0.0001). Late genitourinary and gastrointestinal toxicity grade ≥ 3 (RTOG) was observed in 18 (6.0%) and 7 (2.3%) patients, respectively. Conclusions The main type of treatment failure after 7680 Gy of radiotherapy ± HT is local or metastatic. In all cases, biochemical failure occurred prior to treatment failure. BF within 24 months of treatment completion was significantly associated with worse OS and MFS (AU)
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Prostatic Neoplasms
/
Seminal Vesicles
Limits:
Aged
/
Humans
/
Male
Language:
En
Journal:
Clin. transl. oncol. (Print)
Year:
2021
Document type:
Article