Dopamine D2 receptor antagonist modulates rTMS-induced pain experiences and corticospinal excitability dependent on stimulation targets / El antagonista del receptor de dopamina D2 modula las experiencias de dolor inducidas por rTMS y la excitabilidad corticoespinal dependiendo de los objetivos de estimulación
Int. j. clin. health psychol. (Internet)
; 24(1): [100413], Ene-Mar, 2024. tab, graf, ilus
Article
in English
| IBECS
| ID: ibc-230359
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Both the primary motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC) rTMS have the potential to reduce certain chronic pain conditions. However, the analgesic mechanisms remain unclear, in which M1- and DLPFC-rTMS may have different impact on the release of dopamine receptor D2 neurotransmissions (DRD2). Using a double-blind, randomised, sham- and placebo-controlled design, this study investigated the influence of DRD2 antagonist on rTMS-induced analgesia and corticospinal excitability across the M1 and DLPFC. Healthy participants in each group (M1, DLPFC, or Sham) received an oral dose of chlorpromazine or placebo before the delivery of rTMS in two separate sessions. Heat pain and cortical excitability were assessed before drug administration and after rTMS intervention. DRD2 antagonist selectively abolished the increased heat pain threshold induced by DLPFC stimulation and increased pain unpleasantness. The absence of analgesic effects in DLPFC stimulation was not accompanied by plastic changes in the corticospinal pathway. In contrast, DRD2 antagonist increased corticospinal excitability and rebalanced excitation-inhibition relationship following motor cortex stimulation, although there were no clear changes in pain experiences. These novel findings together highlight the influence of dopaminergic neurotransmission on rTMS-induced analgesia and corticospinal excitability dependent on stimulation targets.(AU)
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Dopamine
/
Receptors, Dopamine D2
/
Chronic Pain
/
Pain Management
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Int. j. clin. health psychol. (Internet)
Year:
2024
Document type:
Article
Institution/Affiliation country:
The Affiliated Hospital of Hangzhou Normal University/China