Impact of Pleural Lavage Cytology Positivity on Early Recurrence After Surgery for Non-Small Cell Lung Cancer / Impacto de la positividad de la citología del lavado pleural en la recurrencia temprana después de la cirugía por cáncer de pulmón de células no pequeñas
Arch. bronconeumol. (Ed. impr.)
; 60(3): 133-142, Mar. 2024. ilus, tab, graf
Article
in English
| IBECS
| ID: ibc-231097
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Objective:
The aim of this study was to elucidate the impact of pleural lavage cytology positivity on early recurrence in patients operated on non-small cell lung cancer (NSCLC).Methods:
This is a multicentre prospective cohort study of 684 patients undergoing an anatomical lung resection for NSCLC between October 2015 and October 2017 at 12 national centres. A pleural lavage was performed before and after lung resection. The association between the different predictors of early recurrence and PLC positivity was performed using univariate and multivariate logistic regression models. A propensity score analysis was performed by inverse probability weighting (IPSW) using average treatment effect (ATE) estimation to analyse the impact of PLC positivity on early recurrence.Results:
Overall PLC positivity was observed in 15 patients (2.2%). After two years, 193 patients (28.2%) relapsed, 182 (27.2%) with a negative PLC and 11 (73.3%) with a positive PLC (p<0.001). Factors associated to early recurrence were adenocarcinoma histology (OR=1.59, 95%CI 1.062.38, p=0.025), visceral pleural invasion (OR=1.59, 95%CI 1.042.4, p=0.03), lymph node involvement (OR=1.84, 95%CI 1.142.96, p=0.013), advanced pathological stage (OR=2.12, 95%CI 1.273.54, p=0.004) and PLC positivity (OR=4.14, 95%CI 1.2516.36, p=0.028). After IPSW, PLC positivity was associated with an increased risk of early recurrence (OR=3.46, 95%CI 2.255.36, p<0.001).Conclusions:
Positive pleural lavage cytology was found to be the strongest predictor of early recurrence.(AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Prognosis
/
Thoracic Surgery
/
Carcinoma, Non-Small-Cell Lung
/
Cell Biology
/
Lung
/
Neoplasm Staging
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Arch. bronconeumol. (Ed. impr.)
Year:
2024
Document type:
Article
Institution/Affiliation country:
Hospital Clínico Universitario de Santiago/Spain
/
Hospital Universitario Arnau de Vilanova/Spain
/
Hospital Universitario Marqués de Valdecilla/Spain
/
Hospital Universitario Miguel Servet/Spain
/
Hospital Universitario Puerta de Hierro/Spain
/
Hospital Universitario de Cruces/Spain