Immunological changes after a single bout of moderate-intensity exercise in a hot environment

ABSTRACT

This study was aimed to evaluate the possible changes caused by a single bout ofmoderate-intensity exercise in a hot environmental temperature on the immune functionand on inflammatory markers. A total of 22 young male adults (VO2max, 55.4 ¡¾3.6 ml¡¤kg-1¡¤min-1) volunteered to participate in an exercise session of 60 minutes on atreadmill ergometer at moderate speed (60% of the maximum aerobic speed) in hotenvironmental conditions (35 ¨¬C and humidity 60%). Total leukocyte numbers, lymphocytesubsets (CD8+, CD4+, CD3+, NK and CD19+), cytokine productioncapacity by peripheral blood mononuclear cells (PBMCs) (IL-2, IL-4, IL-5, IL-10,IFN-¥ã and TNF-¥á) as well as the concentration of several inflammation related proteins(ceruloplasmin, C-reactive protein (CRP), complement factors C3 and C4)were evaluated before and after exercise. The results show that leukocyte and neutrophilabsolute values increased (P<0.001) after the exercise period. In contrast,eosinophil values decreased (P<0.05) after the exercise. In addition, ceruloplasmin,C3 and C4 values (P<0.05) increased after exercise. No changes in T lymphocyte subsets,cytokine production, or CRP were observed. These data confirm previous studiessuggesting that a 60 min exercise in a hot environment is enough to cause a physiologicadaptation to these special conditions leading to an increase of non-specificimmune cells and promoting inflammatory processes. On the other hand, PCR values, lymphocyte subsets and the capacity of cytokine production by PBMC were notchanged in a relatively short bout of exercise under these conditions in contrast withprevious studies (AU)

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