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Quercetin as a potential nutraceutic against coronavirus disease 2019 (COVID-19) / La Quercetina como un potencial nutracéutico contra la enfermedad por coronavirus 2019 (COVID-19)
Brito, Júlio César Moreira; Lima, William Gustavo; Nizer, Waleska Stephanie da Cruz.
Affiliation
  • Brito, Júlio César Moreira; Ezequiel Dias Foundation. Resarch and Development. Belo Horizonte. Brazil
  • Lima, William Gustavo; Federal University of Minas Gerais. Pharmacy School. Department of Clinical Analyses and Toxicology. Belo Horizonte. Brazil
  • Nizer, Waleska Stephanie da Cruz; Carleton University. Department of Health Sciences. Ontario. Canada
Ars pharm ; 62(1): 89-95, ene.-mar. 2021.
Article in English | IBECS | ID: ibc-196716
Responsible library: ES1.1
Localization: BNCS
ABSTRACT

INTRODUCTION:

The coronavirus disease 2019 (COVID-19) is a viral disease that affects several human organs and sys¬tems. Preventive or prophylactic treatments are specifically useful in emerging infectious diseases such as COVID-19 because they reduce the need for hospitalization and public health spending. Although the SARS-CoV-2 preventive effect of several therapeutic agents (e.g., hydroxychloroquine/chloroquine, remdesivir, lopinavir, and ritonavir) has been extensively evaluated, none of them have demonstrated significant clinical efficacy.

METHOD:

We aim to address and discuss the recently published studies on the chemoprophylactic potential of quer¬cetin against SARS-CoV-2. A literature search was carried out on different databases, such as PubMed/MEDLINE, Scielo, Scopus, Web of Science, Cochrane Library, and Clinical Trials.gov. Studies that report the effect of quercetin against SARS-CoV-2 or other types of coronaviruses were included and critically evaluated.

RESULTS:

Studies have shown that quercetin, an FDA-approved flavonoid used as an antioxidant and anti-inflamma¬tory agent, inhibits the entry of coronavirus (SARS-CoV) into the host cell. Moreover, an in silico study showed that quercetin is a potent inhibitor of the SARS-CoV-2 main protease (Mpro), suggesting that this flavonoid is also active against COVID-19.

CONCLUSIONS:

Because quercetin might prevent and lessen the duration of SARS-CoV-2 infections, it is plausible to assume that the prophylactic use of this flavonoid produces several clinical benefits. However, this preliminary evidence needs to be confirmed by in vitro assays and, posteriorly, in randomized clinical trials
RESUMEN

INTRODUCCIÓN:

La enfermedad del coronavirus 2019 (COVID-19) es una enfermedad viral que afecta a varios órganosy sistemas. Los tratamientos preventivos o profilácticos son especialmente útiles en enfermedades infecciosas emergentes como COVID-19 porque reducen la necesidad de hospitalización y el gasto en salud pública. Aunque el efecto preventivo del SARS-CoV-2 de varios agentes terapéuticos (e.g., hidroxicloroquina/cloroquina, remdesivir,lopinavir y ritonavir) se ha evaluado ampliamente, ninguno de ellos ha demostrado una gran eficacia clínica.

MÉTODO:

Por lo tanto, aquí nuestro objetivo es abordar y discutir los estudios publicados recientemente sobre el potencial quimioprofilático de la quercetina contra el SARS-CoV-2.

METODOLOGÍA:

Se realizó una búsqueda de la literaturaen bases como PubMed/MEDLINE, Scielo, Scorpus, Web of Science, Cochrane Library y Clinical Trials.gov. Se incluyeron y evaluaron críticamente estudios que abordan la quercetina contra el SARS-CoV-2 u otros tipos decoronavirus.

RESULTADOS:

Algunos estudios han demostrado que la quercetina, un flavonoide aprobado por la FDA que se utiliza como agente antioxidante y antiinflamatorio, inhibe la entrada del coronavirus (SARS-CoV) en la célula huésped.Además, un estudio in silico mostró que la quercetina es un potente inhibidor de la proteasa principal del SARSCoV-2 (Mpro), lo que sugiere que este flavonoide también es activo contra COVID-19.

CONCLUSIONES:

Debido a que la quercetina podría prevenir y disminuir la duración de las infecciones por SARSCoV-2, es plausible suponer que el uso profiláctico de este flavonoide produce varios beneficios clínicos. Pero, estas pruebas preliminares deben ser confirmadas mediante ensayos in vitro y, posteriormente, en un ensayo clínico aleatorizado
Subject(s)

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Antiviral Agents / Quercetin / Coronavirus Infections / Dietary Supplements / Pre-Exposure Prophylaxis Limits: Humans Language: English Journal: Ars pharm Year: 2021 Document type: Article Institution/Affiliation country: Carleton University/Canada / Ezequiel Dias Foundation/Brazil / Federal University of Minas Gerais/Brazil

Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Antiviral Agents / Quercetin / Coronavirus Infections / Dietary Supplements / Pre-Exposure Prophylaxis Limits: Humans Language: English Journal: Ars pharm Year: 2021 Document type: Article Institution/Affiliation country: Carleton University/Canada / Ezequiel Dias Foundation/Brazil / Federal University of Minas Gerais/Brazil
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