Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells
Braz. j. med. biol. res
; 34(6): 699-709, Jun. 2001. ilus, tab, graf
Article
in En
| LILACS
| ID: lil-285842
Responsible library:
BR1.1
ABSTRACT
The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed. Heparin isolated from shrimp mimics the pharmacological activities of low molecular weight heparins. A heparan sulfate from Artemia franciscana and a dermatan sulfate from tuna fish show a potent heparin cofactor II activity. A heparan sulfate derived from bovine pancreas has a potent antithrombotic activity in an arterial and venous thrombosis model with a negligible activity upon the serine proteases of the coagulation cascade. It is suggested that the antithrombotic activity of heparin and other antithrombotic agents is due at least in part to their action on endothelial cells stimulating the synthesis of an antithrombotic heparan sulfate.
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Endothelium, Vascular
/
Heparin
/
Fibrinolytic Agents
/
Heparitin Sulfate
/
Anticoagulants
Limits:
Animals
/
Humans
Language:
En
Journal:
Braz. j. med. biol. res
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
2001
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil