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Compartmental analysis of ranitidine doubled peak plasma profile after oral administration to healthy volunteers
Schuck, Virna Josiane Aurelio; Costa, Teresa Dalla; Barros, Sérgio G. S. de; Gruber, Carlos; Schapoval, Elfrides Eva Schermann.
Affiliation
  • Schuck, Virna Josiane Aurelio; Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. BR
  • Costa, Teresa Dalla; Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. BR
  • Barros, Sérgio G. S. de; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Hospital de Clínicas de Porto Alegre. BR
  • Gruber, Carlos; Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Hospital de Clínicas de Porto Alegre. BR
  • Schapoval, Elfrides Eva Schermann; Universidade do Rio Grande do Sul. Faculdade de Farmácia. BR
RBCF, Rev. bras. ciênc. farm. (Impr.) ; 38(2): 183-190, abr.-jun. 2002. ilus, tab, graf
Article in En | LILACS | ID: lil-333582
Responsible library: BR40.1
ABSTRACT
The aim of this study was to describe the double peak plasma pharmacokinetic profile of ranitine after oral administration to healthy volunteers using non-compartmental and compartmental analysis. A single 300mg dose of ranitide was given to ten healthy volunteers (5 male and 5 female). Blood samples were drawn at different times and analyzed by HPLC. Plasma profiles were evaluated by non-compartmental and compartmental approaches. The non-compartmental parameters determined were k (0.0054 ñ 0.0010 min-1), t 1/2 (2.2 ñ 0.4 h), Vd steady state/F (265.3 ñ 70.6L), Cl/F (84.8 ñ 24.3 L/h) and AUC (225916 ñ 54099 ng*min/mL)...
Subject(s)
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Plasma / Ranitidine / Digestive System / Gastric Acid Limits: Adult / Female / Humans Language: En Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2002 Document type: Article Affiliation country: Brazil
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Plasma / Ranitidine / Digestive System / Gastric Acid Limits: Adult / Female / Humans Language: En Journal: RBCF, Rev. bras. ciênc. farm. (Impr.) Journal subject: BIOQUIMICA / FARMACIA / FARMACOLOGIA Year: 2002 Document type: Article Affiliation country: Brazil