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The association of genetic markers and malaria infection in the Brazilian Western Amazonian region
Beiguelman, B; Alves, F. P; Moura, M. M; Engracia, V; Nunes, A. C. S; Heckmann, M. I. O; Ferreira, R. G. M; Pereira Da Silva, L. H; Camargo, E. P; Krieger, H.
Affiliation
  • Beiguelman, B; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
  • Alves, F. P; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
  • Moura, M. M; Centro de Pesquisas em Doenças Tropicais. Porto Velho. BR
  • Engracia, V; Centro de Pesquisas em Doenças Tropicais. Porto Velho. BR
  • Nunes, A. C. S; Centro de Pesquisas em Doenças Tropicais. Porto Velho. BR
  • Heckmann, M. I. O; Centro de Pesquisas em Doenças Tropicais. Porto Velho. BR
  • Ferreira, R. G. M; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
  • Pereira Da Silva, L. H; Centro de Pesquisas em Doenças Tropicais. Porto Velho. BR
  • Camargo, E. P; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
  • Krieger, H; Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Parasitologia. São Paulo. BR
Mem. Inst. Oswaldo Cruz ; 98(4): 455-460, June 2003. mapas, tab
Article in En | LILACS | ID: lil-344234
Responsible library: BR1.1
RESUMO
Almost all individuals (182) belonging to an Amazonian riverine population (Portuchuelo, RO, Brazil) were investigated for ascertaining data on epidemiological aspects of malaria. Thirteen genetic blood polymorphisms were investigated (ABO, MNSs, Rh, Kell, and Duffy systems, haptoglobins, hemoglobins, and the enzymes glucose-6-phosphate dehydrogenase, glyoxalase, phosphoglucomutase, carbonic anhydrase, red cell acid phosphatase, and esterase D). The results indicated that the Duffy system is associated with susceptibility to malaria, as observed in other endemic areas. Moreover, suggestions also arose indicating that the EsD and Rh loci may be significantly associated with resistance to malaria. If statistical type II errors and sample stratification could be ruled out, hypotheses on the existence of a causal mechanism or an unknown closely linked locus involved in susceptibility to malaria infection may explain the present

findings:

Subject(s)
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Phenotype / Plasmodium falciparum / Plasmodium vivax / Malaria, Vivax / Malaria, Falciparum / Erythrocytes Type of study: Risk_factors_studies Limits: Animals / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2003 Document type: Article Affiliation country: Brazil
Fulltext
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Phenotype / Plasmodium falciparum / Plasmodium vivax / Malaria, Vivax / Malaria, Falciparum / Erythrocytes Type of study: Risk_factors_studies Limits: Animals / Female / Humans / Male Country/Region as subject: America do sul / Brasil Language: En Journal: Mem. Inst. Oswaldo Cruz Journal subject: MEDICINA TROPICAL / PARASITOLOGIA Year: 2003 Document type: Article Affiliation country: Brazil