Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy
J. venom. anim. toxins incl. trop. dis
; 12(1): 91-109, 2006. tab
Article
in En
| LILACS
| ID: lil-423837
Responsible library:
BR33.1
RESUMO
The aim of this paper was to evaluate the immune reconstitution of HIV-1 patients subjected to highly active antiretroviral therapy (HAART) for two years or more according to CD45RA and CD45RO cell count; determination of IL-2, IFN-gamma, IL-4, IL-10 and TNF-alpha serum levels; CD4+ T and CD8+ T lymphocyte count; and plasma viral load (VL) determination. For this purpose, a cross sectional study was carried out in the Tropical Diseases Area, Botucatu School of Medicine, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil. Between June 2001 and April 2002, 37 HIV-1 infected patients were evaluated, 13 with treatment indication but untreated (G1), 9 subjected to HAART for 5-7 months (G2), and 15 treated for two years or more (G3); both treated groups used medication regularly and without failure. Forty-nine normal individuals were studied as controls (GC-1 and GC-2). There was a tendency (p<0.10) for the predominance of two nucleoside reverse transcriptase inhibitors (NRTI) associated with one non-nucleoside reverse transcriptase inhibitor (NNRTI) regimen in G2; and two NRTI associated with a protease inhibitor (PI) in G3. Statistical differences between groups were seen for CD45RA (G1<[G3=GC-2]; p<0.05) and CD45RO (G1
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Cytokines
/
HIV
/
Anti-HIV Agents
/
Antiretroviral Therapy, Highly Active
/
Immune System
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
TOXICOLOGIA
Year:
2006
Document type:
Article
Affiliation country:
Brazil
Country of publication:
Brazil