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Leucoencefalopatía reversible posterior: cuatro casos clínicos / Reversible posterior leukoencephalopathy syndrome in patients with immunosupressive treatment: Report of four cases
Hernández C., Marta; Núñez F., Alicia; Mesa L., Tomas; Escobar H., Raúl; Barriga C., Francisco; Huete L., Isidro.
Affiliation
  • Hernández C., Marta; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Pediatría, Sección Neurología Infantil. Santiago. CL
  • Núñez F., Alicia; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Pediatría, Sección Neurología Infantil. Santiago. CL
  • Mesa L., Tomas; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Pediatría, Sección Neurología Infantil. Santiago. CL
  • Escobar H., Raúl; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Pediatría, Sección Neurología Infantil. Santiago. CL
  • Barriga C., Francisco; Pontificia Universidad Católica de Chile. Facultad de Medicina. Hemato-oncología. Santiago. CL
  • Huete L., Isidro; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Radiología. Santiago. CL
Rev. méd. Chile ; 136(1): 93-98, ene. 2008. ilus, tab
Article in Es | LILACS | ID: lil-483225
Responsible library: BR1.1
ABSTRACT
Reversible posterior leukoencephalopathy syndrome (PLS) is characterized by headache, clouding of sensorium, visual disturbances and seizures. It is associated to hypertension, renal disease or immunosuppressive therapy. We report three males, aged 9, 12 and 16 years and one female, aged 5 years wih PLS associated to immunosuppressive therapy. All had seizures and three had headache and clouding of sensorium. One case was associated to an hypertensive emergency, one to liver failure and one to high tacrolimus levels. Magnetic resonance imaging showed lesions in the white matter in two patients and in the gray matter in the other two. The lapse between the start of immunosuppressive treatment and neurological symptoms ranged from 4 days to 6 months. All received antiepileptic drugs and immunosuppresive therapy was changed or decreased, with complete clinical recovery.
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Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Tacrolimus / Posterior Leukoencephalopathy Syndrome / Immunosuppressive Agents / Anticonvulsants Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: Es Journal: Rev. méd. Chile Journal subject: MEDICINA Year: 2008 Document type: Article Affiliation country: Chile Country of publication: Chile
Full text: 1 Collection: 01-internacional Database: LILACS Main subject: Tacrolimus / Posterior Leukoencephalopathy Syndrome / Immunosuppressive Agents / Anticonvulsants Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: Es Journal: Rev. méd. Chile Journal subject: MEDICINA Year: 2008 Document type: Article Affiliation country: Chile Country of publication: Chile