La genética como factor pronóstico y terapéutico en el mieloma múltiple: [revisión] / Genetic markers as prognostic factors in multiple myeloma: [revision]
Rev. méd. Chile
; 137(4): 552-558, abr. 2009. tab
Article
in Es
| LILACS
| ID: lil-518591
Responsible library:
BR1.1
ABSTRACT
The search for prognostic factors in multiple myeloma has identified the genetic profile of the tumor as the main determinant of patient survival and response to treatment. There is an association between a dismal prognosis and the presence of t(414) translocations or 17p deletion, determined by fluorescent in situ hybridization (FISH) or the detection of chromosome 13 deletion using conventional cytogenetic techniques. These alterations define a subpopulation that comprises 25% of patients with a bad prognosis even if they are treated with high dose chemotherapy. These patients should be early derived to more specific therapies. In the other hand, the other 75% of patients without a genetic risk factor, have a higher probability of success with conventional treatment.
Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Multiple Myeloma
Type of study:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2009
Document type:
Article
Affiliation country:
Chile
/
United States
Country of publication:
Chile